ArticlePloS one2009
Membrane protein location-dependent regulation by PI3K (III) and rabenosyn-5 in Drosophila wing cells.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- THBS2 as a Key Regulator in Gastrointestinal Tumors: from Molecular Mechanisms to Clinical Applications.Current oncology reports · 2026Review
- Molecular mechanism on autophagy associated cardiovascular dysfunction inFrontiers in cell and developmental biology · 2025Review
- Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin).Autophagy · 2023Article
- Ykt6-dependent endosomal recycling is required for Wnt secretion in theDevelopment (Cambridge, England) · 2020Article
- FGF controls epithelial-mesenchymal transitions during gastrulation by regulating cell division and apicobasal polarity.Development (Cambridge, England) · 2018Article
- Endosome maturation factors Rabenosyn-5/VPS45 and caveolin-1 regulate ciliary membrane and polycystin-2 homeostasis.The EMBO journal · 2018Article
- Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation.Nature cell biology · 2017Article
- Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility.PloS one · 2016Article
- Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor.Molecular cancer · 2015Article
- Atg6/UVRAG/Vps34-containing lipid kinase complex is required for receptor downregulation through endolysosomal degradation and epithelial polarity during Drosophila wing development.BioMed research international · 2014Article
- A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.The EMBO journal · 2012Article
- The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila.Cellular logistics · 2011Article
- α1A-adrenergic receptor induces activation of extracellular signal-regulated kinase 1/2 through endocytic pathway.PloS one · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The class III phosphatidylinositol-3 kinase (PI3K (III)) regulates intracellular vesicular transport at multiple steps through the production of phosphatidylinositol-3-phosphate (PI(3)P). While the localization of proteins at distinct membrane domains are likely regulated in different ways, the roles of PI3K (III) and its effectors have not been extensively investigated in a polarized cell during tissue development. In this study, we examined in vivo functions of PI3K (III) and its effector candidate Rabenosyn-5 (Rbsn-5) in Drosophila wing primordial cells, which are polarized along the apical-basal axis. Knockdown of the PI3K (III) subunit Vps15 resulted in an accumulation of the apical junctional proteins DE-cadherin and Flamingo and also the basal membrane protein beta-integrin in intracellular vesicles. By contrast, knockdown of PI3K (III) increased lateral membrane-localized Fasciclin III (Fas III). Importantly, loss-of-function mutation of Rbsn-5 recapitulated the aberrant localization phenotypes of beta-integrin and Fas III, but not those of DE-cadherin and Flamingo. These results suggest that PI3K (III) differentially regulates localization of proteins at distinct membrane domains and that Rbsn-5 mediates only a part of the PI3K (III)-dependent processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.