ReviewAmerican journal of Alzheimer's disease and other dementias
Obesity and Alzheimer's disease: a link between body weight and cognitive function in old age.
Review in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 2 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Association between metabolic syndrome and the risk of Parkinson's disease: a meta-analysis.BMC neurology · 2024Pooled it
- Obesity and episodic memory function.The journal of physiological sciences : JPS · 2018Pooled it
- Building research in diet and cognition: The BRIDGE randomized controlled trial.Contemporary clinical trials · 2017Trial
- Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity.Scientific reports · 2016Trial
- A randomized trial of a community-based cognitive intervention for obese senior adults.Journal of aging and health · 2013Trial
- Fructose Intake Is Associated with Brain Metabolic Reprogramming and Exacerbation of Alzheimer-like Alterations in APP/PS1 Mice.International journal of molecular sciences · 2026Article
- Adipokines at the Metabolic-Brain Interface: Therapeutic Modulation by Antidiabetic Agents and Natural Compounds in Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Distinct Patterns of Weight Gain, Age, and Subcortical Microstructure in Early Adolescence.JAMA network open · 2025Observational
- Childhood obesity and risk of Alzheimer's disease: a Mendelian randomization study.Archives of public health = Archives belges de sante publique · 2024Article
- Alzheimer's Disease: Causal Effect between Obesity and APOE Gene Polymorphisms.International journal of molecular sciences · 2023Article
- Beyond Weight Loss: Added Benefits Could Guide the Choice of Anti-Obesity Medications.Current obesity reports · 2023Review
- Relationship Between Cognitive Performance, Physical Activity, and Socio-Demographic/Individual Characteristics Among Aging Americans.Journal of Alzheimer's disease : JAD · 2023Article
- Adipose tissue, systematic inflammation, and neurodegenerative diseases.Neural regeneration research · 2023Review
- Impact ofFrontiers in nutrition · 2023Article
- Obesity-Associated Neurodegeneration Pattern Mimics Alzheimer's Disease in an Observational Cohort Study.Journal of Alzheimer's disease : JAD · 2023Observational
- Association between Visceral Adipose Tissue Metabolism and Alzheimer's Disease Pathology.Metabolites · 2022Article
- Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet.GeroScience · 2022Article
- Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models.Neurobiology of disease · 2021Review
- Article
- High-fat diet increases gliosis and immediate early gene expression in APOE3 mice, but not APOE4 mice.Journal of neuroinflammation · 2021Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is now a global health hazard. It not only predisposes to an array of risk factors leading to increased morbidity and mortality amongst adults but it also has a major negative impact on children's health. The deleterious effects of obesity on cardiovascular system have now been well acknowledged. It causes insulin resistance that in turn leads to diabetes, hypertension and cardiovascular abnormalities. The vascular effects of obesity may have a role in the development of a rapidly growing disease of late life, Alzheimer's disease. The precise mechanisms of the association between adiposity and impairment of cognitive performance remain to be elucidated. However, negative impact of obesity on cognitive function may be, at least in part, due to vascular defects, impaired insulin metabolism and signaling pathway or a defect in glucose transport mechanisms in brain. This review examines the available data regarding the impact of obesity on cognitive function.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.