ArticleJournal of neurodevelopmental disorders2009
Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons.
Article in Journal of neurodevelopmental disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Regulation of the E/I-balance by the neural matrisome.Frontiers in molecular neuroscience · 2023Review
- Selective Inhibitory Circuit Dysfunction after Chronic Frontal Lobe Contusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Alpha2-Adrenoblockers Regulate Development of Oxidative Stress and Cognitive Behaviour of Rats under Chronic Acoustic Stress Conditions.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Increased Sociability in Mice Lacking IntergenicFrontiers in neuroscience · 2021Article
- Toward a Better Understanding of Neuronal Migration Deficits in Autism Spectrum Disorders.Frontiers in cell and developmental biology · 2019Review
- A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations.Human molecular genetics · 2018Article
- PAFAH1B1 haploinsufficiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus.Scientific reports · 2017Article
- Neuronal migration disorders: Focus on the cytoskeleton and epilepsy.Neurobiology of disease · 2016Review
- Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia.Molecular neuropsychiatry · 2015Article
- Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments.Molecular psychiatry · 2015Article
- Review
- Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and future perspectives.Psychopharmacology · 2014Review
- Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain.Frontiers in neuroanatomy · 2014Article
- Bridging the interval: theory and neurobiology of trace conditioning.Behavioural processes · 2014Review
- Pleiotropic functions for transcription factor zscan10.PloS one · 2014Article
- Abnormal emotional learning in a rat model of autism exposed to valproic acid in utero.Frontiers in behavioral neuroscience · 2014Article
- The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon.Developmental biology · 2013Article
- Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants.The Journal of comparative neurology · 2013Article
- Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response.Brain, behavior, and immunity · 2012Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledThe inhibitory GABAergic system has been implicated in multiple neuropsychiatric diseases such as schizophrenia and autism. The Dlx homeobox transcription factor family is essential for development and function of GABAergic interneurons. Mice lacking the Dlx1 gene have postnatal subtype-specific loss of interneurons and reduced IPSCs in their cortex and hippocampus. To ascertain consequences of these changes in the GABAergic system, we performed a battery of behavioral assays on the Dlx1 mutant mice, including zero maze, open field, locomotor activity, food intake, rotarod, tail suspension, fear conditioning assays (context and trace), prepulse inhibition, and working memory related tasks (spontaneous alteration task and spatial working memory task). Dlx1 mutant mice displayed elevated activity levels in open field, locomotor activity, and tail suspension tests. These mice also showed deficits in contextual and trace fear conditioning, and possibly in prepulse inhibition. Their learning deficits were not global, as the mutant mice did not differ from the wild-type controls in tests of working memory. Our findings demonstrate a critical role for the Dlx1 gene, and likely the subclasses of interneurons that are affected by the lack of this gene, in behavioral inhibition and associative fear learning. These observations support the involvement of particular components of the GABAergic system in specific behavioral phenotypes related to complex neuropsychiatric diseases. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9025-8) contains supplementary material, which is available to authorized users.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.