ArticleEuropean journal of human genetics : EJHG2010
Genomic landscape of positive natural selection in Northern European populations.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Recent updates on cold adaptation in population and laboratory studies, including cross-adaptation with nonthermal factors.Journal of physiological anthropology · 2025Review
- The adaptive evolution of cancer driver genes.BMC genomics · 2023Article
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- Recombination affects allele-specific expression of deleterious variants in human populations.Science advances · 2022Article
- Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adults.Journal of physiological anthropology · 2021Article
- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020Review
- Population Stratification in Genetic Association Studies.Current protocols in human genetics · 2017Review
- Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.Nature communications · 2017Article
- Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans.Scientific reports · 2017Article
- Fifteen years of genomewide scans for selection: trends, lessons and unaddressed genetic sources of complication.Molecular ecology · 2016Review
- Functional genomics bridges the gap between quantitative genetics and molecular biology.Genome research · 2015Article
- Genomic data as the "hitchhiker's guide" to cattle adaptation: tracking the milestones of past selection in the bovine genome.Frontiers in genetics · 2015Review
- A bioinformatics workflow for detecting signatures of selection in genomic data.Frontiers in genetics · 2014Article
- Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease.American journal of human genetics · 2012Review
- Adaptation and niche construction in human prehistory: a case study from the southern Scandinavian Late Glacial.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
- The emergence of human-evolutionary medical genomics.Evolutionary applications · 2011Article
- Exploring the potential relevance of human-specific genes to complex disease.Human genomics · 2011Review
- Distinct variants at LIN28B influence growth in height from birth to adulthood.American journal of human genetics · 2010Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 3 countries.
Funding
Abstract
Analyzing genetic variation of human populations for detecting loci that have been affected by positive natural selection is important for understanding adaptive history and phenotypic variation in humans. In this study, we analyzed recent positive selection in Northern Europe from genome-wide data sets of 250 000 and 500 000 single-nucleotide polymorphisms (SNPs) in a total of 999 individuals from Great Britain, Northern Germany, Eastern and Western Finland, and Sweden. Coalescent simulations were used for demonstrating that the integrated haplotype score (iHS) and long-range haplotype (LRH) statistics have sufficient power in genome-wide data sets of different sample sizes and SNP densities. Furthermore, the behavior of the F(ST) statistic in closely related populations was characterized by allele frequency simulations. In the analysis of the North European data set, 60 regions in the genome showed strong signs of recent positive selection. Out of these, 21 regions have not been discovered in previous scans, and many contain genes with interesting functions (eg, RAB38, INFG, NOS1AP, and APOE). In the putatively selected regions, we observed a statistically significant overrepresentation of genetic association with complex disease, which emphasizes the importance of the analysis of positive selection in understanding the evolution of human disease. Altogether, this study demonstrates the potential of genome-wide data sets to discover loci that lie behind evolutionary adaptation in different human populations.
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