ArticleThe Journal of biological chemistry2009
Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Single-cell RNA sequencing reveals IgMZoological research · 2026Article
- B cells in anti-tRNA synthetase syndrome patients show an activated, interferon-responsive signature.Frontiers in immunology · 2026Article
- Towards a unifying model for B-cell receptor triggering.Nature reviews. Immunology · 2025Review
- Discrete-state models identify pathway specific B cell states across diseases and infections at single-cell resolution.Journal of theoretical biology · 2024Article
- SMAUG: Analyzing single-molecule tracks with nonparametric Bayesian statistics.Methods (San Diego, Calif.) · 2021Article
- Identification of regenerative processes in neonatal spinal cord injury in the opossum (Monodelphis domestica): A transcriptomic study.The Journal of comparative neurology · 2021Article
- Cytoskeletal control of B cell responses to antigens.Nature reviews. Immunology · 2017Review
- Article
- The Other Function: Class II-Restricted Antigen Presentation by B Cells.Frontiers in immunology · 2017Review
- LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.Scientific reports · 2016Article
- Targeting B-cell receptor signaling in leukemia and lymphoma: how and why?International journal of hematologic oncology · 2016Review
- The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation.Biochimica et biophysica acta · 2014Review
- Synthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling.ACS chemical biology · 2014Article
- Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?Scientifica · 2014Review
- Lupus risk variants in the PXK locus alter B-cell receptor internalization.Frontiers in genetics · 2014Article
- The actin cytoskeleton coordinates the signal transduction and antigen processing functions of the B cell antigen receptor.Frontiers in biology · 2013Article
- Development of EHop-016: a small molecule inhibitor of Rac.The Enzymes · 2013Review
- Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments.Nature immunology · 2011Article
- Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy.Molecular immunology · 2011Review
- A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity.Immunologic research · 2011Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The signal transduction events supporting B cell antigen receptor (BCR) endocytosis are not well understood. We have identified a pathway supporting BCR internalization that begins with tyrosine phosphorylation of the adapter protein LAB. Phosphorylated LAB recruits a complex of Grb2-dynamin and the guanine nucleotide exchange factor Vav. Vav is required for activation of the small GTPases Rac1 and Rac2. All these proteins contribute to (and dynamin, Vav, and Rac1/2 are required for) BCR endocytosis and presentation of antigen to T cells. This is the first description of a sequential signal transduction pathway from BCR to internalization and antigen presentation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.