Trial reportDiabetologia2010
Determinants of urinary albumin excretion within the normal range in patients with type 2 diabetes: the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study.
Trial report in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00185159 (Randomized Olmesartan and Diabetes Microalbuminuria Prevention Study), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Olmesartan and Diabetes Microalbuminuria Prevention Study (ROADMAP)
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Antihypertensive agents for preventing diabetic kidney disease.The Cochrane database of systematic reviews · 2012Pooled it
- CUBN is a gene locus for albuminuria.Journal of the American Society of Nephrology : JASN · 2011Pooled it
- L/N-type calcium channel blocker cilnidipine reduces plasma aldosterone, albuminuria, and urinary liver-type fatty acid binding protein in patients with chronic kidney disease.Heart and vessels · 2013Trial
- Low-Grade Albuminuria Is Associated with Metabolic Syndrome and Its Components in Middle-Aged and Elderly Chinese Population.PloS one · 2013Trial
- Resting heart rate and the risk of microvascular complications in patients with type 2 diabetes mellitus.Journal of the American Heart Association · 2012Trial
- Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label study.Clinical drug investigation · 2011Trial
- Association Between Dipstick Hematuria and Elevated Albuminuria in a Hospital-Based Population with Diverse Chronic Conditions.Diagnostics (Basel, Switzerland) · 2026Article
- Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Observational
- Detection of Lower Albuminuria Levels and Early Development of Diabetic Kidney Disease Using an Artificial Intelligence-Based Rule Extraction Approach.Diagnostics (Basel, Switzerland) · 2019Article
- Clinical Trials on Diabetic Nephropathy: A Cross-Sectional Analysis.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Article
- Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease.Pharmacological research · 2017Review
- Predictive modeling using a nationally representative database to identify patients at risk of developing microalbuminuria.International urology and nephrology · 2016Article
- All Components of Metabolic Syndrome Are Associated with Microalbuminuria in a Chinese Population.PloS one · 2016Article
- High-normal urinary albumin-to-creatinine ratio is independently associated with metabolic syndrome in Chinese patients with type 2 diabetes mellitus: A cross-sectional community-based study.Journal of diabetes investigation · 2015Article
- Glycated peptides are associated with proximal tubule dysfunction in type 2 diabetes mellitus.International journal of clinical and experimental medicine · 2015Article
- Normal range albuminuria and metabolic syndrome in South Korea: the 2011-2012 Korean National Health and Nutrition Examination Survey.PloS one · 2015Article
- Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.Diabetologia · 2014Article
- Observational
- Proteinuria and its relation to cardiovascular disease.International journal of nephrology and renovascular disease · 2013Review
- Prevalence of abnormal urinary albumin excretion in elderly people: a Spanish survey.International urology and nephrology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 11 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisIn contrast to microalbuminuric type 2 diabetic patients, the factors correlated with urinary albumin excretion are less well known in normoalbuminuric patients. This may be important because even within the normoalbuminuric range, higher rates of albuminuria are known to be associated with higher renal and cardiovascular risk.
methodsAt the time of screening for the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) Study, the urinary albumin/creatinine ratio (UACR) was 0.44 mg/mmol in 4,449 type 2 diabetic patients. The independent correlates of UACR were analysed.
resultsIndependent correlates of UACR during baseline were (in descending order): night-time systolic BP (r(s) = 0.19); HbA(1c) (r(s) = 0.18); mean 24 h systolic BP (r(s) = 0.16); fasting blood glucose (r(s) = 0.16); night-time diastolic BP (r(s) = 0.12); office systolic BP, sitting (r(s) = 0.11), standing (r(s) = 0.10); estimated GFR (r(s) = 0.10); heart rate, sitting (r(s) = 0.10); haemoglobin (r(s) = -0.10); triacylglycerol (r(s) = 0.09); and uric acid (r(s) = -0.08; all p <or= 0.001). Significantly higher albumin excretion rates were found for the following categorical variables: higher waist circumference (more marked in men); presence of the metabolic syndrome; smoking (difference more marked in males); female sex; antihypertensive treatment; use of amlodipine; insulin treatment; family history of diabetes; and family history of cardiovascular disease (more marked in women). CONCLUSIONS/
interpretationAlthough observational correlations do not prove causality, in normoalbuminuric type 2 diabetic patients the albumin excretion rate is correlated with many factors that are potentially susceptible to intervention.
trial registrationClinicalTrials.gov ID no.: NCT00185159
fundingThis study was sponsored by Daichii-Sankyo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.