ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Regulation of radial glial motility by visual experience.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the DevelopingInternational journal of molecular sciences · 2023Article
- Glia Regulate the Development, Function, and Plasticity of the Visual System From Retina to Cortex.Frontiers in neural circuits · 2022Review
- Müller Glia in Retinal Development: From Specification to Circuit Integration.Frontiers in neural circuits · 2021Review
- Nutrient restriction causes reversible G2 arrest inDevelopment (Cambridge, England) · 2019Article
- The Gliotransmitter d-Serine Promotes Synapse Maturation and Axonal StabilizationThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neural Activity-Dependent Regulation of Radial Glial Filopodial Motility Is Mediated by Glial cGMP-Dependent Protein Kinase 1 and Contributes to Synapse Maturation in the Developing Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the DevelopingFrontiers in cellular neuroscience · 2016Article
- Rules for Shaping Neural Connections in the Developing Brain.Frontiers in neural circuits · 2016Review
- An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system.Developmental biology · 2015Article
- HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum.PloS one · 2015Article
- In vivo Calcium Imaging of Evoked Calcium Waves in the Embryonic Cortex.Frontiers in cellular neuroscience · 2015Article
- Characterization of the BAC Id3-enhanced green fluorescent protein transgenic mouse line for in vivo imaging of astrocytes.Neurophotonics · 2014Article
- Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets.Disease models & mechanisms · 2013Review
- Computer aided alignment and quantitative 4D structural plasticity analysis of neurons.Neuroinformatics · 2013Article
- Improved method for the quantification of motility in glia and other morphologically complex cells.Neural plasticity · 2013Article
- Global hyper-synchronous spontaneous activity in the developing optic tectum.Scientific reports · 2013Article
- Neuronal-glial Interactions Define the Role of Nitric Oxide in Neural Functional Processes.Current neuropharmacology · 2012Article
- In vivo time-lapse imaging of cell proliferation and differentiation in the optic tectum of Xenopus laevis tadpoles.The Journal of comparative neurology · 2012Article
- Visual activity regulates neural progenitor cells in developing xenopus CNS through musashi1.Neuron · 2010Article
- In vivo spike-timing-dependent plasticity in the optic tectum of Xenopus laevis.Frontiers in synaptic neuroscience · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Radial glia in the developing optic tectum express the key guidance molecules responsible for topographic targeting of retinal axons. However, the extent to which the radial glia are themselves influenced by retinal inputs and visual experience remains unknown. Using multiphoton live imaging of radial glia in the optic tectum of intact Xenopus laevis tadpoles in conjunction with manipulations of neural activity and sensory stimuli, radial glia were observed to exhibit spontaneous calcium transients that were modulated by visual stimulation. Structurally, radial glia extended and retracted many filopodial processes within the tectal neuropil over minutes. These processes interacted with retinotectal synapses and their motility was modulated by nitric oxide (NO) signaling downstream of neuronal NMDA receptor (NMDAR) activation and visual stimulation. These findings provide the first in vivo demonstration that radial glia actively respond both structurally and functionally to neural activity, via NMDAR-dependent NO release during the period of retinal axon ingrowth.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.