ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Endothelin receptors: what's new and what do we need to know?
Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Treatment of thromboangiitis obliterans (Buerger's disease) with bosentan.BMC cardiovascular disorders · 2012Trial
- Role of endothelial dysfunction in the severity of COVID‑19 infection (Review).Molecular medicine reports · 2022Review
- Understanding the molecular mechanism of endothelin ETBiophysical journal · 2022Article
- The effects of botulinum toxin A and papaverine on human saphenous vein and internal mammary artery grafts: anArchives of medical science : AMS · 2022Article
- Article
- Ovarian hormones modulate endothelin-1 receptor responses in young women.Microcirculation (New York, N.Y. : 1994) · 2018Article
- Chronic Blockade of Brain Endothelin Receptor Type-A (ETInternational journal of molecular sciences · 2018Article
- Human Cytomegalovirus Up-Regulates Endothelin Receptor Type B: Implication for Vasculopathies?Open forum infectious diseases · 2015Article
- Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts.Arthritis research & therapy · 2015Article
- Adaptations of the endothelin system after exercise training in a porcine model of ischemic heart disease.Microcirculation (New York, N.Y. : 1994) · 2015Article
- Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.Life sciences · 2014Article
- Interception of the endotoxin-induced arterial hyporeactivity to vasoconstrictors.Vascular pharmacology · 2014Article
- Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing.PloS one · 2014Article
- Arsenic-stimulated lipolysis and adipose remodeling is mediated by G-protein-coupled receptors.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Bidirectional neuro-glial signaling modalities in the hypothalamus: role in neurohumoral regulation.Autonomic neuroscience : basic & clinical · 2013Review
- Arsenic activates endothelin-1 Gi protein-coupled receptor signaling to inhibit stem cell differentiation in adipogenesis.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.British journal of pharmacology · 2013Review
- Cerebrovascular consequences of obstructive sleep apnea.Journal of the American Heart Association · 2012Article
- Vascular endothelin receptor type B: structure, function and dysregulation in vascular disease.Biochemical pharmacology · 2012Review
- EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Receptors are at the heart of how a molecule transmits a signal to a cell. Two receptor classes for endothelin (ET) are recognized, the ET(A) and ET(B) receptors. Intriguing questions have arisen in the field of ET receptor pharmacology, physiology, and function. For example, a host of pharmacological studies support the interaction of the ET(A) and ET(B) receptor in tissues (veins, arteries, bronchus, arterioles, esophagus), but yet few have been able to demonstrate direct ET(A)/ET(B) receptor interaction. Have we modeled this interaction wrong? Do we have a truly selective ET(A) receptor agonist such that we could selectively stimulate this important receptor? What can we learn from the recent phylogenic studies of the ET receptor family? Have we adequately addressed the number of biological molecules with which ET can interact to exert a biological effect? Recent mass spectrometry studies in our laboratory suggest that ET-1 interacts with other hereto unrecognized proteins. Biased ligands (ligands at the same receptor that elicit distinct signaling responses) have been discovered for other receptors. Do these exist for ET receptors and can we take advantage of this possibility in drug design? These and other questions will be posed in this minireview on topics on ET receptors.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.