ArticleThe international journal of biochemistry & cell biology2010
Chemico-genetic identification of drebrin as a regulator of calcium responses.
Article in The international journal of biochemistry & cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Structural mechanisms of drebrin-mediated F-actin network modulation.Nature communications · 2026Article
- BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entry.Journal of virology · 2025Article
- CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.Cancers · 2022Review
- Drebrin Regulates Acetylcholine Receptor Clustering and Organization of Microtubules at the Postsynaptic Machinery.International journal of molecular sciences · 2021Article
- ORAI1 CaFrontiers in cell and developmental biology · 2021Review
- CaAdvances in cancer research · 2020Review
- Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction.Frontiers in cellular neuroscience · 2018Article
- Article
- Role of Drebrin at the Immunological Synapse.Advances in experimental medicine and biology · 2017Review
- Store-operated CRAC channel inhibitors: opportunities and challenges.Future medicinal chemistry · 2016Review
- SOCE and cancer: Recent progress and new perspectives.International journal of cancer · 2016Review
- Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction.Nature communications · 2015Article
- T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors.Frontiers in immunology · 2015Review
- Article
- In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold?British journal of pharmacology · 2013Review
- Presenilin conditional double knockout mice exhibit decreases in drebrin a at hippocampal CA1 synapses.Synapse (New York, N.Y.) · 2012Article
- Regulation of myotube formation by the actin-binding factor drebrin.Skeletal muscle · 2011Article
- Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2.The international journal of biochemistry & cell biology · 2011Article
- Pharmacology of store-operated calcium channels.Molecular interventions · 2010Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Store-operated calcium channels are plasma membrane Ca(2+) channels that are activated by depletion of intracellular Ca(2+) stores, resulting in an increase in intracellular Ca(2+) concentration, which is maintained for prolonged periods in some cell types. Increases in intracellular Ca(2+) concentration serve as signals that activate a number of cellular processes, however, little is known about the regulation of these channels. We have characterized the immuno-suppressant compound BTP, which blocks store-operated channel mediated calcium influx into cells. Using an affinity purification scheme to identify potential targets of BTP, we identified the actin reorganizing protein, drebrin, and demonstrated that loss of drebrin protein expression prevents store-operated channel mediated Ca(2+) entry, similar to BTP treatment. BTP also blocks actin rearrangements induced by drebrin. While actin cytoskeletal reorganization has been implicated in store-operated calcium channel regulation, little is known about actin-binding proteins that are involved in this process, or how actin regulates channel function. The identification of drebrin as a mediator of this process should provide new insight into the interaction between actin rearrangement and store-operated channel mediated calcium influx.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.