ArticleProceedings of the National Academy of Sciences of the United States of America1991
In vitro apolipoprotein B mRNA editing: identification of a 27S editing complex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 104 citations in OpenAlex.
- Review
- APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A.Nucleic acids research · 2021Article
- Article
- APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.RNA (New York, N.Y.) · 2017Article
- Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Functions and regulation of the APOBEC family of proteins.Seminars in cell & developmental biology · 2012Review
- APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers.Biochemical and biophysical research communications · 2010Article
- The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells.Biochemical and biophysical research communications · 2010Article
- Functional characterization of APOBEC-1 complementation factor phosphorylation sites.Biochimica et biophysica acta · 2007Article
- Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor.Nucleic acids research · 2006Article
- Transcript abundance supercedes editing efficiency as a factor in developmental variation of chloroplast gene expression.RNA (New York, N.Y.) · 2002Article
- Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization.The Biochemical journal · 2001Article
- Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase.Nucleic acids research · 2001Article
- Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.Molecular and cellular biology · 2000Article
- APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast.Nucleic acids research · 2000Article
- Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase.The Biochemical journal · 1999Article
- A sequence-specific RNA-binding protein complements apobec-1 To edit apolipoprotein B mRNA.Molecular and cellular biology · 1998Article
- Apolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing.Nucleic acids research · 1998Article
- Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- RNA editing in kinetoplastid protozoa.Microbiology and molecular biology reviews : MMBR · 1997Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Specific apolipoprotein B (apoB) mRNA editing can be performed in vitro on apoB RNA substrates. Native gels and glycerol gradient sedimentation have been used to determine the physical properties of the in vitro editing activity in rat liver cytosolic S100 extracts. ApoB RNA substrates were progressively assembled as 27S complexes for 3 hr with similar kinetics as seen for the accumulation of edited RNA. Assembly was not observed on RNAs from apoB deletion constructs that did not support editing. The 27S complex contained both edited and unedited RNA sequences. Inhibition of 27S complex assembly by vanadyl-ribonucleoside complexes was accompanied by inhibition of editing. Based on these data, we propose that the 27S complex is the in vitro "editosome," A "mooring sequence" model for RNA recognition and editosome assembly has been proposed involving RNA sequences flanking the edited nucleotide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.