ArticleDiabetes care2010
Minimal contribution of fasting hyperglycemia to the incidence of type 2 diabetes in subjects with normal 2-h plasma glucose.
Article in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Higher adiposity predicts greater intra-individual inconsistencies in postprandial glycemic measurements-an analysis of three randomized controlled trials in Asian populations.European journal of clinical nutrition · 2024Trial
- Trial
- Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range.The Journal of clinical endocrinology and metabolism · 2014Trial
- Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis.Diabetes research and clinical practice · 2011Trial
- Impact on cardiometabolic risk of a weight loss intervention with higher protein from lean red meat: Combined results of 2 randomized controlled trials in obese middle-aged and older adults.Journal of clinical lipidologyTrial
- Feasibility of using OGTT 1-h PG as a diagnostic criterion for diabetes and pre-diabetes.BMJ open diabetes research & care · 2026Article
- Article
- Bimodal distribution of fasting, one and two hour post load plasma glucose in Asian Indian pregnant women without pre-gestational diabetes: Gestational age related changes.Journal of clinical & translational endocrinology · 2019Article
- The shape of the glucose concentration curve during an oral glucose tolerance test predicts risk for type 1 diabetes.Diabetologia · 2018Article
- Normal fasting plasma glucose predicts type 2 diabetes and cardiovascular disease in elderly population in Taiwan.QJM : monthly journal of the Association of Physicians · 2016Article
- Predictability of 1-h postload plasma glucose concentration: A 10-year retrospective cohort study.Journal of diabetes investigation · 2015Article
- [Screening and prevention of diabetes].Der Internist · 2015Article
- Treatment of prediabetes.World journal of diabetes · 2015Review
- Oral glucose tolerance test-based calculation identifies different glucose intolerance phenotypes within the impaired fasting glucose range.Journal of diabetes investigation · 2014Article
- Depressive symptoms linked to 1-h plasma glucose concentrations during the oral glucose tolerance test in men and women with the metabolic syndrome.Diabetic medicine : a journal of the British Diabetic Association · 2014Article
- Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin.International journal of endocrinology · 2014Article
- Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose.Current diabetes reports · 2013Article
- Pathophysiology of prediabetes and treatment implications for the prevention of type 2 diabetes mellitus.Endocrine · 2013Review
- Osteocalcin and the Regulation of Glucose Metabolism.Clinical reviews in bone and mineral metabolism · 2013Article
- The association of genetic markers for type 2 diabetes with prediabetic status - cross-sectional data of a diabetes prevention trial.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE To assess the relative contribution of increased fasting and postload plasma glucose concentrations to the incidence of type 2 diabetes in subjects with a normal 2-h plasma glucose concentration. RESEARCH DESIGN AND METHODS A total of 3,450 subjects with 2-h plasma glucose concentration <140 mg/dl at baseline were followed up in the San Antonio Heart Study (SAHS) and the Botnia Study for 7-8 years. The incidence of type 2 diabetes at follow-up was related to the fasting, 1-h, and 2-h plasma glucose concentrations. RESULTS In subjects with 2-h plasma glucose <140 mg/dl, the incidence of type 2 diabetes increased with increasing fasting plasma glucose (FPG) and 1-h and 2-h plasma glucose concentrations. In a multivariate logistic analysis, after adjustment for all diabetes risk factors, the FPG concentration was a strong predictor of type 2 diabetes in both the SAHS and the Botnia Study (P < 0.0001). However, when the 1-h plasma glucose, but not 2-h plasma glucose, concentration was added to the model, FPG concentration was no longer a significant predictor of type 2 diabetes in both studies (NS). When subjects were matched for the level of 1-h plasma glucose concentration, the incidence of type 2 diabetes markedly increased with the increase in 1-h plasma glucose, but the increase in FPG was not associated with a significant increase in the incidence of type 2 diabetes. CONCLUSIONS An increase in postload glycemia in the normal range is associated with an increase in the incidence of type 2 diabetes. After controlling for 1-h plasma glucose concentration, the increase in FPG concentration is not associated with an increase in the incidence of type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.