Evidence map›Paper›PMID 20009950›Full record

ReviewJournal of clinical gastroenterology2010

Clinical practice: diagnosis and evaluation of dyspepsia.

David Yates Graham, Massimo Rugge

Open access · greenAbstract readReview
In one paragraph

Review in Journal of clinical gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Diagnostic utility of alarm features in predicting malignancy in patients with dyspeptic symptoms.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021
    Observational
  3. Comparison of clinical symptoms afterNew microbes and new infections · 2020
    Article
  4. Autoimmune gastritis.Nature reviews. Disease primers · 2020
    Review
  5. Article
  6. Clinical guidelines: Secondary prevention of gastric cancer.Nature reviews. Gastroenterology & hepatology · 2012
    Article
  7. Article
  8. Community pharmacy-basedCanadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC
    Article
  9. Journal of microscopy and ultrastructure
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

David Yates GrahamDepartment of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine Houston, Texas, USA. dgraham@bcm.tmc.edu
Massimo Rugge
Baylor College of Medicine · USIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Obesity, H pylori and Risk of Barrett's EsophagusR01CA116845 · NCI · BAYLOR COLLEGE OF MEDICINE · PI EL-SERAG, HASHEM B · 2007 to 2011
$2.8M
NCI NIH HHS R01 CA116845NIDDK NIH HHS DK56338NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

The main issue regarding the approach to the patient with uninvestigated dyspepsia is whether the symptoms are the result of an important clinical illness, which then determines the appropriate management strategy for the treatment of the symptoms. An initial trial of empiric antisecretory drugs is recommended for those without Helicobacter pylori infection and no alarm symptoms, whereas H. pylori eradication is recommended for those with an active H. pylori infection. Treatment expectations for H. pylori infections should theoretically be similar to other common infectious diseases. In most regions, clarithromycin resistance has undermined traditional triple therapy so that it is no longer a suitable choice as an empiric therapy. Four drug therapies, such as sequential, concomitant, and bismuth-quadruple therapy are generally still acceptable choices as empiric therapies. Posteradication testing is highly recommended to provide early identification of otherwise unrecognized increasing antimicrobial resistance. However, despite the ability to successfully cure H. pylori infections, a symptomatic response can be expected in only a minority of those with dyspepsia not associated with ulcers (so called nonulcer dyspepsia). Overall, from the patients stand point, symptomatic relief is often difficult to achieve and physicians must rely on reassurance along with empiric and individualized care.

Indexed as

AdultAnti-Bacterial AgentsClarithromycinDrug Resistance, BacterialDrug Therapy, CombinationDyspepsiaHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedAnti-Bacterial AgentsClarithromycin

Identifiers

PMID20009950
PMCPMC2828509
OpenAlexW2010921900

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.