ReviewPflugers Archiv : European journal of physiology2010
The multiple actions of NO.
Review in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 136 citations in OpenAlex.
- Clinical applications of PET imaging for evaluating treatment-induced vascular toxicity in oncology.Current opinion in hematology · 2026Review
- Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia.PLoS computational biology · 2026Article
- NO-cGMP Signaling in Endothelial Function of the Healthy and Inflamed Dental Pulp.International journal of molecular sciences · 2025Review
- Importance of selected genetic determinants on endurance performance and physical strength: a narrative review.Frontiers in physiology · 2025Review
- Keeping the beat against time: Mitochondrial fitness in the aging heart.Frontiers in aging · 2022Review
- Genetic characteristics of competitive swimmers: a review.Biology of sport · 2022Review
- Indoxyl sulfate enhances endothelin-1-induced contraction via impairment of NO/cGMP signaling in rat aorta.Pflugers Archiv : European journal of physiology · 2021Article
- The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches.International journal of molecular sciences · 2021Review
- The Association of Multiple Gene Variants with Ageing Skeletal Muscle Phenotypes in Elderly Women.Genes · 2020Article
- The role of neuronal nitric oxide and its pathways in the protection and recovery from neurotoxin-inducedAIMS neuroscience · 2019Article
- TheBiology of sport · 2018Article
- Acute inhibition of PMCA4, but not global ablation, reduces blood pressure and arterial contractility via a nNOS-dependent mechanism.Journal of cellular and molecular medicine · 2018Article
- Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia.Frontiers in aging neuroscience · 2018Review
- Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease.Circulation research · 2017Review
- The Relationship between Estrogen and Nitric Oxide in the Prevention of Cardiac and Vascular Anomalies in the Developing Zebrafish (Danio Rerio).Brain sciences · 2016Article
- Article
- Endothelial and Smooth Muscle Cell Interactions in the Pathobiology of Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2016Review
- Evaluation of the Nano-TiO2 as a Novel Deswelling Material.Molecules (Basel, Switzerland) · 2016Article
- Mitochondrial Quality Control as a Therapeutic Target.Pharmacological reviews · 2016Review
- Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide.The Journal of biological chemistry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies in the last two decades have firmly established that nitric oxide (NO) exerts a broad range of effects on bodily functions including muscle contractility, platelet aggregation, metabolism, neuronal activity, and immune responses. The underlying mechanisms rely primarily on elevating guanosine 3',5'-cyclic monophosphate due to the stimulation of soluble guanylyl cyclase, inhibiting mitochondria respiration by the action on cytochrome C oxidase, and nitrosylating proteins and enzymes. Under pathophysiological conditions, an increased production of NO concurrently with an enhanced generation of superoxide leads to the formation of peroxynitrite, a potent oxidative agent, and thus tissue injuries. This article intends to provide a brief review on the effects of NO in the modulations of muscle contractility, platelet aggregation, metabolism, neuronal activity, and immune responses. The actions of NO vary depending on the interactions between this gaseous molecule, its derivates, and their effectors as well as the local redox environments. Considering the complexity of these interactions and the widespread presence of NO in various body systems and cell types, there is no doubt that this area of research will remain very challenging and rewarding in the foreseeable future.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.