Evidence map›Paper›PMID 20063935›Full record

Trial reportHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2010

The impact of cognitive function on medication management: three studies.

Carol S Stilley, Catherine M Bender, Jacqueline Dunbar-Jacob, Susan Sereika, Christopher M Ryan

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Senior adult oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2012
    Guideline
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  10. Postoperative cognitive dysfunction and mortality following lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Trial
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  16. Reduced expression of N-methyl-D-aspartate receptor and calcium signaling genes in gray matter is associated with cancer-related cognitive impairment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  17. Article
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carol S StilleyCenter for Research in Chronic Disorders (CRCD), School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. css100@pitt.edu
Catherine M Bender
Jacqueline Dunbar-Jacob
Susan Sereika
Christopher M Ryan

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Long Term Trajectory of Cognitive Function Related to Anastrozole Use in WomenR01CA107408 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENDER, CATHERINE M. · 2005 to 2015
$3.8M
Core--Statistics and Data ManagementP30NR003924 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNBAR-JACOB, JACQUELINE M · 1994 to 2008
$3.1M
IMPROVING MEDICATION ADHERENCE IN COMORBID CONDITIONSR01DK059048 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNBAR-JACOB, JACQUELINE M · 2000 to 2004
$2.6M
NCATS NIH HHS UL1 TR000005NCI NIH HHS R01 CA107408NIDDK NIH HHS R01 DK059048NIDDK NIH HHS R01 DK59048NINR NIH HHS 2 P30 NR003924-15NINR NIH HHS P30 NR003924PHS HHS 5U01HLO 48992-02
6 · The paper itself

Abstract

objectiveMedication nonadherence has been a persistent problem over the past three decades; forgetting and being distracted from regular routines are the barriers most frequently cited by patients. Prior research on cognitive function and medication adherence has yielded mixed results.

designThis report compares findings of three studies: All were longitudinal, two were randomized controlled intervention trials, and one was descriptive. Samples of adult patients taking once daily lipid-lowering medication, diabetic patients with comorbid conditions on complex regimens, and early stage breast cancer patients on hormonal therapy completed similar batteries of standardized, valid, neuropsychological tests at baseline.

main outcome measuresAdherence to medication regimens, over time, was tracked with electronic event monitors.

resultsMedication nonadherence was prevalent in all studies. Deficits in attention/mental flexibility and/or working memory predicted nonadherence in all studies; impaired executive function was related to poor adherence in one study.

conclusionThese findings suggest that better mental efficiency may be the key to better medication adherence with any regimen, and that targeted cognitive functions, which can be easily and quickly assessed, may identify patients at risk of poor adherence regardless of diagnosis or regimen.

Indexed as

AdultAttitude to HealthCognition DisordersDrug TherapyFemaleHumansMaleMental DisordersMiddle AgedNeuropsychological TestsPatient ComplianceYoung Adult

Identifiers

PMID20063935
PMCPMC2807986

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.