Evidence map›Paper›PMID 20082925›Full record

ArticleJournal of the American College of Cardiology2009

Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition?

Karen A Matthews, Sybil L Crawford, Claudia U Chae, Susan A Everson-Rose, Mary Fran Sowers, Barbara Sternfeld, Kim Sutton-Tyrrell

Registry-linked trialOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06975111 (Focusing on the Menopausal Transition to Improve Mid-Life Women's Health), which is not on this map. Cited by 333 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
333citing papers in PubMed, 4 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06975111 phase2 / phase3recruitingstarted 2026, after this paper: background citation

Focusing on the Menopausal Transition to Improve Mid-Life Women's Health

Ran2026Enrolled200Registered outcomes10Posted comparisons0ConditionsCardiovascular, Menopause, Menopause Hot Flashes, Menopause Related ConditionsArmsAnti-hypertensives, Fezolinetant, Hormonal therapy, Life Style Intervention, Lipid Lowering Medication
PMID 26789348PMID 22990755PMID 19470968PMID 18663170PMID 1285753PMID 39480425PMID 34415665PMID 35041662PMID 35797481PMID 37900422PMID 38178979PMID 33764994other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

333 citing papers in PubMed, 4 syntheses or guidelines pooled it, 649 citations in OpenAlex.

  1. Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Arquivos brasileiros de cardiologia · 2024
    Guideline
  2. Pooled it
  3. Pooled it
  4. Cardiovascular Changes in Menopause.Current cardiology reviews · 2021
    Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. A single dose of dietary nitrate supplementation protects against endothelial ischemia-reperfusion injury in early postmenopausal women.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2022
    Trial
  9. Trial
  10. Article
  11. Review
  12. Article
  13. Observational
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

273 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Karen A MatthewsDepartment of Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA. matthewska@upmc.edu
Sybil L Crawford
Claudia U Chae
Susan A Everson-Rose
Mary Fran Sowers
Barbara Sternfeld
Kim Sutton-Tyrrell
University of Pittsburgh · USHarvard University · USKaiser Permanente · USUniversity of Massachusetts Chan Medical School · USUniversity of Michigan · USUniversity of Minnesota · US

Funding

WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1994 to 2005
$8.4M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1994 to 2005
$7.8M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1994 to 2005
$7.4M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · UNIVERSITY OF CALIFORNIA DAVIS · 1994 to 2005
$4.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1994 to 2005
$4.5M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · RUSH UNIVERSITY MEDICAL CENTER · 1994 to 2005
$4.4M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · 1994 to 2005
$4.0M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1994 to 2005
$4.0M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · MASSACHUSETTS GENERAL HOSPITAL · 1994 to 2005
$3.3M
NIA NIH HHS AG012495NIA NIH HHS AG012505NIA NIH HHS AG012531NIA NIH HHS AG012535NIA NIH HHS AG012539NIA NIH HHS AG012546NIA NIH HHS AG012553NIA NIH HHS AG012554NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NINR NIH HHS NR004061NINR NIH HHS U01 NR004061
6 · The paper itself

Abstract

objectivesThis prospective study examined whether changes in traditional and novel coronary heart disease (CHD) risk factors are greater within a year of the final menstrual period (FMP), relative to changes that occur before or after that interval, in a multiethnic cohort.

backgroundUnderstanding the influence of menopause on CHD risk remains elusive and has been evaluated primarily in Caucasian samples.

methodsSWAN (Study of Women's Health Across the Nation) is a prospective study of the menopausal transition in 3,302 minority (African American, Hispanic, Japanese, or Chinese) and Caucasian women. After 10 annual examinations, 1,054 women had achieved an FMP not due to surgery and without hormone therapy use before FMP. Measured CHD risk factors included lipids and lipoproteins, glucose, insulin, blood pressure, fibrinogen, and C-reactive protein. We assessed which of 2 models provided a better fit with the observed risk factor changes over time in relation to the FMP: a linear model, consistent with chronological aging, or a piecewise linear model, consistent with ovarian aging.

resultsOnly total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B demonstrated substantial increases within the 1-year interval before and after the FMP, consistent with menopause-induced changes. This pattern was similar across ethnic groups. The other risk factors were consistent with a linear model, indicative of chronological aging.

conclusionsWomen experience a unique increase in lipids at the time of the FMP. Monitoring lipids in perimenopausal women should enhance primary prevention of CHD.

Indexed as

AgingBlood GlucoseBlood PressureCardiovascular DiseasesCholesterolC-Reactive ProteinFactor VIIFemaleFibrinogenHumansInsulinLinear ModelsLipoproteinsLongitudinal StudiesMiddle AgedPerimenopauseBlood GlucoseCholesterolC-Reactive ProteinFactor VIIFibrinogenInsulinLipoproteinsPlasminogen Activator Inhibitor 1Triglycerides

Identifiers

PMID20082925
PMCPMC2856606
OpenAlexW2039535075

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.