Evidence map›Paper›PMID 20096096›Full record

ArticleGenome biology2010

Genome-wide prediction of transcription factor binding sites using an integrated model.

Kyoung-Jae Won, Bing Ren, Wei Wang

Open access · goldAbstract read
In one paragraph

Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
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  4. Fish-Ing for Enhancers in the Heart.International journal of molecular sciences · 2021
    Review
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  12. Cis-regulatory determinants of MyoD function.Nucleic acids research · 2018
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Kyoung-Jae WonUniversity of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Drive, La Jolla, CA 92093, USA. kwon@ucsd.edu
Bing Ren
Wei Wang
University of California, San Diego · USLudwig Cancer Research · US

Funding

Reconstructing Regulation Networks of Meiosis in SilicoR01GM072856 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, WEI · 2005 to 2009
$1.7M
NIGMS NIH HHS R01GM072856
6 · The paper itself

Abstract

We present an integrated method called Chromia for the genome-wide identification of functional target loci of transcription factors. Designed to capture the characteristic patterns of transcription factor binding motif occurrences and the histone profiles associated with regulatory elements such as promoters and enhancers, Chromia significantly outperforms other methods in the identification of 13 transcription factor binding sites in mouse embryonic stem cells, evaluated by both binding (ChIP-seq) and functional (RNA interference knockdown) experiments.

Indexed as

GenomeAmino Acid MotifsAnimalsBinding SitesChromatinChromatin ImmunoprecipitationComputational BiologyEmbryonic Stem CellsEnhancer Elements, GeneticMiceModels, GeneticPromoter Regions, GeneticRNA InterferenceROC CurveTranscription FactorsChromatinTranscription Factors

Identifiers

PMID20096096
PMCPMC2847719
OpenAlexW2078034709

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.