Evidence mapPaperPMID 20103558Full record

ArticleDiabetes care2010

Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits.

Daniel J Drucker, Steven I Sherman, Fred S Gorelick, Richard M Bergenstal, Robert S Sherwin, John B Buse

4 registry-linked trialsAbstract read
In one paragraph

Article in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 115 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 4 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03004612 phase4completedstarted 2016, after this paper: background citation

Effect of Linagliptin + Metformin vs Metformin Alone on the Role of Pancreatic Islet Function, Insulin Resistance and Markers of Cardiovascular Risk in Patients With Prediabetes: Randomized Clinical Trial

Ran2016Enrolled144Registered outcomes5Posted comparisons0ConditionsInsulin Resistance, Prediabetic StateArmsLinagliptin + metformin, Metformin
Open the trial in the graph
NCT04131582 phase3unknown statusstarted 2019, after this paper: background citation

Effect of a Quadruple Therapy on Pancreatic Islet Function, Insulin Resistance and Cardiovascular Function in Patients With Mixed Prediabetes and Obesity: Randomized Clinical Trial

Ran2019Enrolled34Registered outcomes4Posted comparisons0ConditionsInsulin Resistance, Prediabetic StateArmsLinagliptin + metformin and Empagliflozin + metformin, Metformin
Open the trial in the graph
NCT01991197 phase2completednot on this mapstarted 2014, after this paper: background citation

Dipeptidyl Peptidase-4 Inhibition in Psoriasis Patients With Diabetes (DIP): A Randomized Clinical Trial.

TypeinterventionalSponsorUniversity College DublinRan2014 to 2016Enrolled20ConditionsPsoriasis, Type 2 Diabetes MellitusArmsSitagliptin, Gliclazide, Sitagliptin matched placebo, Gliclazide matched placebo capsule
NCT02347501 phase2completednot on this mapstarted 2013, after this paper: background citation

Dipeptidyl Peptidase-4 Inhibition and Narrow-band Ultraviolet-B Light in Psoriasis (DINUP): A Randomised Clinical Trial

TypeinterventionalSponsorUniversity College DublinRan2013 to 2016Enrolled118ConditionsPsoriasisArmsSitagliptin (Januvia)
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Trial
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  10. Review
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  12. GLP-1 receptor agonism: a transformative approach for managing type-2 diabetes and obesity.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. GLP-1 receptor agonists-another promising therapy for Alport syndrome?Journal of rare diseases (Berlin, Germany) · 2025
    Review
  17. Review
  18. Review
  19. Glycolipids Derived from the Korean Endemic PlantPlants (Basel, Switzerland) · 2024
    Article
  20. Review

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Daniel J DruckerDepartment of Medicine, Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Ontario, Canada. d.drucker@utoronto.ca
Steven I Sherman
Fred S Gorelick
Richard M Bergenstal
Robert S Sherwin
John B Buse

Funding

TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · YALE UNIVERSITY · 1986 to 2025
$1.5M
NIDDK NIH HHS T32 DK007017
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diabetes Mellitus, Type 2Drug Administration ScheduleExenatideGlucagon-Like Peptide 1HumansHypoglycemic AgentsIncidenceIncretinsPeptidesPrevalenceRisk AssessmentTreatment OutcomeVenomsExenatideGlucagon-Like Peptide 1Hypoglycemic AgentsIncretinsPeptidesVenoms

Identifiers

PMID20103558
PMCPMC2809297

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.