ArticleMolecules (Basel, Switzerland)2010
Antiproliferative effect and ultrastructural alterations induced by psilostachyin on Trypanosoma cruzi.
Article in Molecules (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- New insights into the pro-oxidant mechanism of dehydroleucodine on Trypanosoma cruzi.Scientific reports · 2024Article
- A comprehensive phytochemical and pharmacological review on sesquiterpenes from the genusHeliyon · 2022Review
- Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease.Frontiers in pharmacology · 2019Review
- Germacranolide-type sesquiterpene lactones from Smallanthus sonchifolius with promising activity against Leishmania mexicana and Trypanosoma cruzi.Parasites & vectors · 2017Article
- Repeated-dose toxicity of common ragweed on rats.PloS one · 2017Article
- Mode of Action of the Sesquiterpene Lactones Psilostachyin and Psilostachyin C on Trypanosoma cruzi.PloS one · 2016Article
- Biogenic trypanocidal sesquiterpenes: lead compounds to design future trypanocidal drugs - a mini review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
- Antioxidant and relaxant activity of fractions of crude methanol extract and essential oil of Artemisia macrocephala Jacquem.BMC complementary and alternative medicine · 2013Article
- Natural terpenoids from Ambrosia species are active in vitro and in vivo against human pathogenic trypanosomatids.PLoS neglected tropical diseases · 2013Article
- Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Trypanocidal Activity of Smallanthus sonchifolius: Identification of Active Sesquiterpene Lactones by Bioassay-Guided Fractionation.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia.Evidence-based complementary and alternative medicine : eCAM · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of psilostachyin, a natural sesquiterpene lactone, on the growth and viability of cultured epimastigotes of Trypanosoma cruzi (Tulahuen) is reported. The antiproliferative effect was evaluated by counting the parasites in a Neubauer chamber and measuring their viability by using the dye exclusion technique. The effect on parasite growth was irreversible at concentrations higher than 1.0 microg/mL and the addition of glutathione only partially blocked the effect of the compound. Moreover, we have studied the effects of this natural compound on parasite ultrastructure by transmission electron microscopy. Interestingly, psilostachyin induced ultrastructural alterations on the parasites at a concentration of 0.5 microg/mL, with important mitochondrial swelling and deformity of the kinetoplast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.