ArticleJournal of the American College of Cardiology2010
Evaluation of cuff-induced ischemia in the lower extremity by magnetic resonance oximetry.
Article in Journal of the American College of Cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Impact of supervised exercise on skeletal muscle blood flow and vascular function measured with MRI in patients with peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2013Trial
- Exploring the Dynamics of Ischemia and Reactive Hyperemia With Skeletal Muscle Blood Oxygen Level Dependent MRI in Patients With Peripheral Artery Disease, Age-Matched Controls, and Young Healthy Subjects.Journal of magnetic resonance imaging : JMRI · 2026Article
- Article
- Clinical physiology: the crucial role of MRI in evaluation of peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2024Review
- Arterial occlusion duration affects the cuff-induced hyperemic response in skeletal muscle BOLD perfusion imaging as shown in young healthy subjects.Magma (New York, N.Y.) · 2023Article
- Clinical characteristics and risk factors of lower extremity amputation in the diabetic inpatients with foot ulcers.Frontiers in endocrinology · 2023Article
- Use of perfusional CBCT imaging for intraprocedural evaluation of endovascular treatment in patients with diabetic foot: a concept paper.Acta bio-medica : Atenei Parmensis · 2020Article
- A Case of Cerebral Hyperperfusion Showing Unique Characteristics on Susceptibility-weighted MR Imaging after Carotid Endarterectomy.NMC case report journal · 2020Article
- Quantitative and Dynamic MRI Measures of Peripheral Vascular Function.Frontiers in physiology · 2020Review
- Near-infrared spectroscopy-derived muscle oxygen saturation on a 0% to 100% scale: reliability and validity of the Moxy Monitor.Journal of biomedical optics · 2019Article
- Observational
- Recent advances in magnetic resonance imaging for peripheral artery disease.Vascular medicine (London, England) · 2018Review
- Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption.Magnetic resonance in medicine · 2018Article
- Assessment of veins in T2*-weighted MR angiography predicts infarct growth in hyperacute ischemic stroke.PloS one · 2018Article
- Susceptibility-based time-resolved whole-organ and regional tissue oximetry.NMR in biomedicine · 2017Review
- Pulse sequence programming in a dynamic visual environment: SequenceTree.Magnetic resonance in medicine · 2016Article
- Comparison of MRI methods for measuring whole-brain venous oxygen saturation.Magnetic resonance in medicine · 2015Article
- Novel magnetic resonance imaging end points for physiologic studies in peripheral arterial disease: elegance versus practicality.Circulation. Cardiovascular imaging · 2015Article
- Multiparametric assessment of vascular function in peripheral artery disease: dynamic measurement of skeletal muscle perfusion, blood-oxygen-level dependent signal, and venous oxygen saturation.Circulation. Cardiovascular imaging · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe aim of this study was to evaluate vascular function in the lower extremities by making direct time-course measurement of oxygen saturation in the femoral/popliteal arteries and veins during cuff-induced reactive hyperemia with magnetic resonance imaging-based oximetry.
backgroundMagnetic resonance imaging-based oximetry is a new calibration-free technique taking advantage of the paramagnetic nature of blood that depends on the volume fraction of deoxyhemoglobin in red blood cells.
methodsWe compared post-occlusive blood oxygenation time-course of femoral/popliteal vessels in: 1) young healthy subjects (YH) (n = 10; mean ankle-brachial index [ABI] 1.0 +/- 0.1, mean age 30 +/- 7 years); 2) peripheral arterial disease (PAD) patients (n = 12; mean ABI 0.6 +/- 0.1, mean age 71 +/- 9 years); and 3) age-matched healthy control subjects (AHC) (n = 8; mean ABI 1.1 +/- 0.1, mean age 68 +/- 9 years). Blood oxygenation was quantified at 3.0-T field strength with a field mapping pulse sequence yielding the magnetic susceptibility difference between blood in the vessels and surrounding muscle tissue from which the intravascular blood oxygen saturation is computed as %HbO(2).
resultsSignificantly longer washout time (42 +/- 16 s vs. 14 +/- 4 s; p < 0.0001) and lower upslope (0.60 +/- 0.20 %HbO(2)/s vs. 1.32 +/- 0.41 %HbO(2)/s; p = 0.0008) were observed for PAD patients compared with healthy subjects (YH and AHC combined). Furthermore, greater overshoot was observed in YH than in AHC (21 +/- 8 %HbO(2) vs. 10 +/- 5 %HbO(2); p = 0.0116).
conclusionsPost-occlusive transient changes in venous blood oxygenation might provide a new measure of vascular competence, which was found to be reduced in subjects with abnormal ABI, manifesting in prolonged recovery during the early phase of hyperemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.