ArticleProceedings of the National Academy of Sciences of the United States of America2010
Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- A primordial germ cell-like-cell platform enables CRISPRi screen for epigenetic fertility modifiers.EMBO reports · 2025Article
- Reflections and perspectives on epigenetically mediated biological control: compromises in cancer and skeletal pathology.Academia biology · 2025Article
- Sublinear scaling of the cellular proteome with ploidy.Nature communications · 2022Article
- BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner.PloS one · 2022Article
- RUNX2 co-operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers.Journal of cellular physiology · 2020Article
- Article
- Identification of GA-Binding Protein Transcription Factor Alpha Subunit (GABPA) as a Novel Bookmarking Factor.International journal of molecular sciences · 2019Article
- Article
- Nuclear organization mediates cancer-compromised genetic and epigenetic control.Advances in biological regulation · 2018Review
- The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation.The Journal of biological chemistry · 2017Article
- Identifying Nuclear Matrix-Attached DNA Across the Genome.Journal of cellular physiology · 2017Article
- Article
- Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identity and Cell Growth.Advances in experimental medicine and biology · 2017Review
- Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Chromatin proteins and RNA are associated with DNA during all phases of mitosis.Cell discovery · 2016Article
- CBFβ and the leukemogenic fusion protein CBFβ-SMMHC associate with mitotic chromosomes to epigenetically regulate ribosomal genes.Journal of cellular biochemistry · 2014Article
- Identification of novel variants in colorectal cancer families by high-throughput exome sequencing.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Mitotic bookmarking by transcription factors.Epigenetics & chromatin · 2013Article
- Review
- The role for runt related transcription factor 2 (RUNX2) as a transcriptional repressor in luteinizing granulosa cells.Molecular and cellular endocrinology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Epigenetic control of ribosomal RNA (rRNA) gene transcription by cell type-specific regulators, such as the osteogenic transcription factor Runx2, conveys cellular memory of growth and differentiation to progeny cells during mitosis. Here, we examined whether coregulatory proteins contribute to epigenetic functions that are mitotically transmitted by Runx2 in osteoblastic cells. We show that the transcriptional corepressor Transducin Like Enhancer-1 (TLE1) associates with rRNA genes during mitosis and interphase through interaction with Runx2. Mechanistically, depletion of TLE1 relieves Runx2-mediated repression of rRNA genes transcription and selectively increases histone modifications linked to active transcription. Biologically, loss of TLE-dependent rRNA gene repression coincides with increased global protein synthesis and enhanced cell proliferation. Our findings reinforce the epigenetic marking target genes by phenotypic transcription factors in mitosis and demonstrate a requirement for retention of coregulatory factors to sustain physiological control of gene expression during proliferation of lineage committed cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.