ArticleProceedings of the National Academy of Sciences of the United States of America2010
Cellular in vivo imaging reveals coordinated regulation of pituitary microcirculation and GH cell network function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- The effect of growth hormone-releasing hormone on cognition and brain connectivity in adults with cognition ranging from normal to mild cognitive impairment.eNeurologicalSci · 2026Article
- BDNF regulates pituitary stem cell engagement toward precursor state.Stem cell reports · 2026Article
- BDNF Regulates Pituitary Stem Cell Engagement towards precursor state.bioRxiv : the preprint server for biology · 2026Article
- Update on regulation of GHRH and its actions on GH secretion in health and disease.Reviews in endocrine & metabolic disorders · 2025Review
- Paracrine FGF1 signaling directs pituitary architecture and size.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- Resistance exercise stress: theoretical mechanisms for growth hormone processing and release from the anterior pituitary somatotroph.European journal of applied physiology · 2023Review
- Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain.JCI insight · 2023Article
- An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.PloS one · 2023Article
- Modeling pulsativity in the hypothalamic-pituitary-adrenal hormonal axis.Scientific reports · 2022Article
- Functional Pituitary Networks in Vertebrates.Frontiers in endocrinology · 2020Review
- Molecular Mechanisms of Pituitary Cell Plasticity.Frontiers in endocrinology · 2020Review
- The Pituitary Tumors and Their Tumor-Specific Microenvironment.Advances in experimental medicine and biology · 2020Article
- Imaging and Manipulating Pituitary Function in the Awake Mouse.Endocrinology · 2019Article
- Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis.Nature communications · 2017Article
- Advances in Understanding of Structural Reorganization in the Hypothalamic Neurosecretory System.Frontiers in endocrinology · 2017Review
- Three-dimensional ultrastructural analyses of anterior pituitary gland expose spatial relationships between endocrine cell secretory granule localization and capillary distribution.Scientific reports · 2016Article
- Minireview: intraislet regulation of insulin secretion in humans.Molecular endocrinology (Baltimore, Md.) · 2013Review
- In vivo recordings of GnRH neuron firing reveal heterogeneity and dependence upon GABAA receptor signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
Growth hormone (GH) exerts its actions via coordinated pulsatile secretion from a GH cell network into the bloodstream. Practically nothing is known about how the network receives its inputs in vivo and releases hormones into pituitary capillaries to shape GH pulses. Here we have developed in vivo approaches to measure local blood flow, oxygen partial pressure, and cell activity at single-cell resolution in mouse pituitary glands in situ. When secretagogue (GHRH) distribution was modeled with fluorescent markers injected into either the bloodstream or the nearby intercapillary space, a restricted distribution gradient evolved within the pituitary parenchyma. Injection of GHRH led to stimulation of both GH cell network activities and GH secretion, which was temporally associated with increases in blood flow rates and oxygen supply by capillaries, as well as oxygen consumption. Moreover, we observed a time-limiting step for hormone output at the perivascular level; macromolecules injected into the extracellular parenchyma moved rapidly to the perivascular space, but were then cleared more slowly in a size-dependent manner into capillary blood. Our findings suggest that GH pulse generation is not simply a GH cell network response, but is shaped by a tissue microenvironment context involving a functional association between the GH cell network activity and fluid microcirculation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.