ArticlePloS one2010
Muscle sympathetic nerve activity is related to a surrogate marker of endothelial function in healthy individuals.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03912909 (Effects of SGLT-2 Inhibition on Sympathetic Nervous System Activity in Humans), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of SGLT-2 Inhibition on Sympathetic Nervous System Activity in Humans
Who cites it
22 citing papers in PubMed.
- Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long-Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab-Based Chemotherapy.Journal of the American Heart Association · 2026Article
- Endothelial dysfunction in single ventricle physiology and the Fontan circulation - What lies ahead.International journal of cardiology. Congenital heart disease · 2025Review
- The Influence of the Sympathetic Nervous System on Cardiometabolic Health in Response to Weight Gain or Weight Loss.Metabolites · 2025Review
- Does endothelial ischemic reperfusion injury augment sympathetic neurovascular transduction?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- High-glycemic index meal acutely potentiates blood pressure response to static handgrip exercise in healthy humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Sympathetic Neural Overdrive, Aortic Stiffening, Endothelial Dysfunction, and Impaired Exercise Capacity in Severe COVID-19 Survivors: A Mid-Term Study of Cardiovascular Sequelae.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Self-reported total sitting time on a non-working day is associated with blunted flow-mediated vasodilation and blunted nitroglycerine-induced vasodilation.Scientific reports · 2022Article
- Clinical Relevance of the Sympathetic-Vascular Interactions in Health and Disease.Biomedicines · 2021Review
- Standard exercise stress testing attenuates peripheral microvascular function in patients with suspected coronary microvascular dysfunction.BMC sports science, medicine & rehabilitation · 2021Article
- Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension.Journal of clinical medicine · 2020Article
- Arterial Stiffness and Endothelial Function in Young Obese Patients - Vascular Resistance Matters.Journal of atherosclerosis and thrombosis · 2019Article
- Effect of Different Classes of Antihypertensive Drugs on Endothelial Function and Inflammation.International journal of molecular sciences · 2019Review
- Article
- Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease.PloS one · 2017Article
- The count of tender rather than swollen joints correlates with aortic stiffness in patients with rheumatoid arthritis.SpringerPlus · 2016Article
- The Relationship between Vascular Function and the Autonomic Nervous System.Annals of vascular diseases · 2014Review
- Assessment of endothelial dysfunction in childhood obesity and clinical use.Oxidative medicine and cellular longevity · 2013Review
- Sympathetic regulation of vascular function in health and disease.Frontiers in physiology · 2012Article
- Sympathetic nervous system activity in health and disease-advances with microneurographic recordings.Frontiers in physiology · 2012Article
- Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence from animal studies indicates the importance of an interaction between the sympathetic nervous system and the endothelium for cardiovascular regulation. However the interaction between these two systems remains largely unexplored in humans. The aim of this study was to investigate whether directly recorded sympathetic vasoconstrictor outflow is related to a surrogate marker of endothelial function in healthy individuals. METHODS AND
resultsIn 10 healthy normotensive subjects (3 f/7 m), (age 37+/-11 yrs), (BMI 24+/-3 kg/m(2)) direct recordings of sympathetic action potentials to the muscle vascular bed (MSNA) were performed and endothelial function estimated with the Reactive Hyperaemia- Peripheral Arterial Tonometry (RH-PAT) technique. Blood samples were taken and time spent on leisure-time physical activities was estimated. In all subjects the rate between resting flow and the maximum flow, the Reactive Hyperemic index (RH-PAT index), was within the normal range (1.9-3.3) and MSNA was as expected for age and gender (13-44 burst/minute). RH-PAT index was inversely related to MSNA (r = -0.8, p = 0.005). RH-PAT index and MSNA were reciprocally related to time (h/week) spent on physical activity (p = 0.005 and p = 0.006 respectively) and platelet concentration (PLT) (p = 0.02 and p = 0.004 respectively).
conclusionsOur results show that sympathetic nerve activity is related to a surrogate marker of endothelial function in healthy normotensive individuals, indicating that sympathetic outflow may be modulated by changes in endothelial function. In this study time spent on physical activity is identified as a predictor of sympathetic nerve activity and endothelial function in a group of healthy individuals. The results are of importance in understanding mechanisms underlying sympathetic activation in conditions associated with endothelial dysfunction and emphasise the importance of a daily exercise routine for maintenance of cardiovascular health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.