ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2010
Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 36 citations in OpenAlex.
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- Anthracycline-induced cardiotoxicity: From pathobiology to identification of molecular targets for nuclear imaging.Frontiers in cardiovascular medicine · 2022Review
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- Advanced imaging modalities to detect cardiotoxicity.Current problems in cancer · 2018Review
- Comprehensive review on cardio-oncology: Role of multimodality imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
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- Cardiorespiratory fitness in breast cancer patients: a call for normative values.Journal of the American Heart Association · 2014Review
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- Doxorubicin Cardiotoxicity and Cardiac Function Improvement After Stem Cell Therapy Diagnosed by Strain Echocardiography.Journal of cancer science & therapy · 2013Article
- Non-invasive imaging and monitoring cardiotoxicity of cancer therapeutic drugs.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Review
- Altered sympathetic nervous system signaling in the diabetic heart: emerging targets for molecular imaging.American journal of nuclear medicine and molecular imaging · 2012Article
- Dissecting myocardial signal transduction cascades: Sharp new insights from multi-tracer molecular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Article
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAltered sympathetic nervous system signaling is known to play a role in the cardiotoxicity of the anthracycline chemotherapeutic agents, but the interaction of pre- and postsynaptic function is not well understood. METHODS AND
resultsOur aim was to study the noradrenergic signaling in an established rat model of adriamycin cardiotoxicity (15 mg/kg administered i.p. over 2 weeks) using radiotracers having potential applicability for imaging with positron emission tomography (PET). Ex vivo biodistribution was performed 1 and 3 weeks post-adriamycin treatment with the noradrenaline analogue [(11)C]meta-hydroxyephedrine ([(11)C]HED), beta-adrenergic receptor antagonist [(3)H]CGP12177, and phosphodiesterase-4 inhibitor (R)-[(11)C]rolipram. Cardiac function (echocardiographic parameters) and heart/body weight ratio were not affected. Myocardial retention of [(11)C]HED, [(3)H]CGP12177, and (R)-[(11)C]rolipram were unchanged 1 week post-adriamycin. Compared to controls, 3 weeks post-treatment [(3)H]CGP12177 uptake decreased (left ventricle free wall and septum; P < 0.05), while [(11)C]HED and (R)-[(11)C]rolipram uptake were unaffected. Following acute increase in myocardial noradrenaline levels with desipramine treatment, (R)-[(11)C]rolipram retention increased in the left atrium, right ventricle, left ventricle free wall and septum (P < 0.05) in vehicle-, but not adriamycin-treated animals.
conclusionOur results suggest that adriamycin-induced toxicity exhibits no change in presynaptic noradrenaline uptake, but decreased beta-adrenergic receptors in cardiac tissues, supporting a role for PET imaging of noradrenaline signaling in the study of anthracycline cardiotoxicity.
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