Evidence mapPaperPMID 20195269Full record

ReviewNature reviews. Endocrinology2010

Transplantation of adipose tissue and stem cells: role in metabolism and disease.

Thien T Tran, C Ronald Kahn

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 1 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 1 synthesis or guideline pooled it, 325 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  15. Food & nutrition research · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Rna MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article

89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Thien T TranJoslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA.
C Ronald Kahn
Harvard University · USJoslin Diabetes Center · US

Funding

Diabetes Genome Anatomy Project (DGAP)R01DK060837 · JOSLIN DIABETES CENTER · 2002 to 2005
$12.5M
Developmental genes, miRNAs and adipose tissueR01DK082659 · JOSLIN DIABETES CENTER · 2025 to 2025
$701k
NIDDK NIH HHS R01 DK060837NIDDK NIH HHS R01 DK082659
6 · The paper itself

Abstract

Humans and other mammals have three main adipose tissue depots: visceral white adipose tissue, subcutaneous white adipose tissue and brown adipose tissue, each of which possesses unique cell-autonomous properties. In contrast to visceral adipose tissue, which can induce detrimental metabolic effects, subcutaneous white adipose tissue and brown adipose tissue have the potential to benefit metabolism by improving glucose homeostasis and increasing energy consumption. In addition, adipose tissue contains adipose-derived stem cells, which possess the ability to differentiate into multiple lineages, a property that might be of value for the repair or replacement of various damaged cell types. Adipose tissue transplantation has primarily been used as a tool to study physiology and for human reconstructive surgery. Transplantation of adipose tissue is, however, now being explored as a possible tool to promote the beneficial metabolic effects of subcutaneous white adipose tissue and brown adipose tissue, as well as adipose-derived stem cells. Ultimately, the clinical applicability of adipose tissue transplantation for the treatment of obesity and metabolic disorders will reside in the achievable level of safety, reliability and efficacy compared with other treatments.

Indexed as

Stem Cell TransplantationAdipose TissueAnimalsDiseaseHumansMetabolic DiseasesMetabolismModels, BiologicalObesityStem Cells

Identifiers

PMID20195269
PMCPMC4362513
OpenAlexW2064433079

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.