ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Maternal low protein diet and fetal programming of lean type 2 diabetes.World journal of diabetes · 2022Review
- Excess sucrose intake during pregnancy programs fetal brain glucocorticoid receptor expression in female but not male C57Bl/6J mice.Obesity science & practice · 2021Article
- Maternal Nutrition and Offspring Stress Response-Implications for Future Development of Non-Communicable Disease: A Perspective From India.Frontiers in psychiatry · 2019Review
- Effects of voluntary exercise on blood pressure, angiotensin II, aldosterone, and renal function in two-kidney, one-clip hypertensive rats.Integrated blood pressure control · 2017Article
- The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models.Journal of translational medicine · 2016Article
- Sustained elevation of NF-κB activity sensitizes offspring of maternal inflammation to hypertension via impairing PGC-1α recovery.Scientific reports · 2016Article
- Current Concepts of Maternal Nutrition.Obstetrical & gynecological survey · 2016Review
- Study protocol: Mother and Infant Nutritional Assessment (MINA) cohort study in Qatar and Lebanon.BMC pregnancy and childbirth · 2016Article
- Review
- Maternal high fat diet consumption during the perinatal period programs offspring behavior.Physiology & behavior · 2014Review
- Prematurity and programming: contribution of neonatal Intensive Care Unit interventions.Journal of developmental origins of health and disease · 2013Article
- High-fat/fructose feeding during prenatal and postnatal development in female rats increases susceptibility to renal and metabolic injury later in life.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Metabolic adaptations to early life protein restriction differ by offspring sex and post-weaning diet in the mouse.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2012Article
- Developmental programming of hypertension and kidney disease.International journal of nephrology · 2012Article
- Low Birth Weight due to Intrauterine Growth Restriction and/or Preterm Birth: Effects on Nephron Number and Long-Term Renal Health.International journal of nephrology · 2012Article
- Paternal body mass index (BMI) is associated with offspring intrauterine growth in a gender dependent manner.PloS one · 2012Article
- Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats.Cardiovascular diabetology · 2011Article
- Prenatal Programming and Epigenetics in the Genesis of the Cardiorenal Syndrome.Cardiorenal medicine · 2011Article
- Article
- Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood.Neuroendocrinology · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Low birth weight humans often exhibit hypertension during adulthood. Studying the offspring of rat dams fed a maternal low-protein diet is one model frequently used to study the mechanisms of low birth weight-related hypertension. It remains unclear whether this model replicates key clinical findings of hypertension and increased blood pressure responsiveness to stress or high-salt diet. We measured blood pressure via radiotelemetry in 13-wk-old male offspring of maternal normal- and low-protein dams. Neither group exhibited hypertension at baseline; however, 1 h of restraint was accompanied by a significantly greater blood pressure response in low-protein compared with normal-protein offspring. To enhance the effect of a high-salt diet on blood pressure, normal- and low-protein offspring underwent right uninephrectomy, while controls underwent sham surgery. After 5 weeks on a high-salt diet (4% NaCl), mean arterial pressure in the Low-Protein+Sham offspring was elevated by 6 +/- 2 mmHg (P < 0.05 vs. baseline), while it remained unchanged in the normal-protein offspring. In the two uninephrectomized groups, blood pressure increased further, but was of similar magnitude. Glomerular filtration rate in the low-protein uninephrectomized offspring was 50% less than that in normal-protein offspring with intact kidneys. These data indicate that, while male low-protein offspring are not hypertensive during young adulthood, their blood pressure is hyperresponsive to restraint stress and is salt sensitive, and their glomerular filtration rate is more sensitive to hypertension-causing insults. Collectively, these may predispose for the development of hypertension later in life.
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