ArticleThe Journal of biological chemistry2010
G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR).
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Serotonin Receptors in Myocardial Infarction: Friend or Foe?ACS chemical neuroscience · 2024Review
- Gq Signaling in Autophagy Control: Between Chemical and Mechanical Cues.Antioxidants (Basel, Switzerland) · 2022Review
- Targeting G protein-coupled receptor signalling by blocking G proteins.Nature reviews. Drug discovery · 2018Review
- CCL20 triggered by chemotherapy hinders the therapeutic efficacy of breast cancer.PLoS biology · 2018Article
- The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling inG3 (Bethesda, Md.) · 2017Article
- Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.Respiratory research · 2017Article
- Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.The Journal of biological chemistry · 2016Article
- Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion.Circulation · 2015Article
- ERK5 Mediated Signalling in Diabetic Retinopathy.Medical hypothesis, discovery & innovation ophthalmology journal · 2015Review
- A new non-canonical pathway of Gα(q) protein regulating mitochondrial dynamics and bioenergetics.Cellular signalling · 2014Article
- ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment.PloS one · 2013Article
- Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.The Journal of biological chemistry · 2012Article
- Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis.Cellular signalling · 2011Article
- Identification of a novel binding partner of phospholipase cβ1: translin-associated factor X.PloS one · 2010Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G(q)-coupled G protein-coupled receptors (GPCR) mediate the actions of a variety of messengers that are key regulators of different cellular functions. These receptors can regulate a highly interconnected network of biochemical routes that control the activity of several members of the mitogen-activated protein kinase (MAPK) family. The ERK5 MAPK has been shown to be activated by G(q)-coupled GPCR via unknown mechanisms. We find that the atypical protein kinase C (PKCzeta), previously reported to interact with the ERK5 activator MEK5 and to be involved in epidermal growth factor-mediated ERK5 stimulation, plays a crucial role in the activation of the ERK5 pathway by G(q)-coupled GPCR. Stimulation of ERK5 by G(q)-coupled GPCR is abolished upon pharmacological inhibition of PKCzeta as well as in embryonic fibroblasts obtained from PKCzeta-deficient mice. Both PKCzeta and MEK5 associate to G alpha(q) upon activation of GPCR, thus forming a ternary complex that seems essential for the activation of ERK5. These data put forward a novel function of G alpha(q) as a scaffold protein involved in the modulation of the ERK5 cascade by GPCR that could be relevant in G(q)-mediated physiological functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.