Evidence map›Paper›PMID 20201852›Full record

ReviewAnnals of the New York Academy of Sciences2010

Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction.

Stephanie C Licata, Perry F Renshaw

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 5 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 syntheses or guidelines pooled it, 121 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016
    Trial
  7. Trial
  8. Review
  9. Higher striatal glutamate in male youth with internet gaming disorder.European archives of psychiatry and clinical neuroscience · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. CaTranslational psychiatry · 2021
    Article
  16. Article
  17. Article
  18. Review
  19. Motion correction in magnetic resonance spectroscopy.Magnetic resonance in medicine · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Stephanie C LicataBehavioral Psychopharmacology Research Laboratory, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02478, USA. slicata@mclean.harvard.edu
Perry F Renshaw
McLean Hospital · USUniversity of Utah · US

Funding

fMRI Studies Investigating the Choice Effects of Sedative/HypnoticsK01DA023659 · NIDA · MCLEAN HOSPITAL · PI LICATA, STEPHANIE C · 2007 to 2010
$601k
NIDA NIH HHS K01 DA023659NIDA NIH HHS K01DA023659NIDA NIH HHS K24DA151116
6 · The paper itself

Abstract

Proton magnetic resonance spectroscopy ((1)H MRS) is a noninvasive imaging technique that permits measurement of particular compounds or metabolites within the tissue of interest. In the brain, (1)H MRS provides a snapshot of the neurochemical environment within a defined volume of interest. A search of the literature demonstrates the widespread utility of this technique for characterizing tumors, tracking the progress of neurodegenerative disease, and for understanding the neurobiological basis of psychiatric disorders. As of relatively recently, (1)H MRS has found its way into substance abuse research, and it is beginning to become recognized as a valuable complement in the brain imaging toolbox that also contains positron emission tomography, single-photon-emission computed tomography, and functional magnetic resonance imaging. Drug abuse studies using (1)H MRS have identified several biochemical changes in the brain. The most consistent alterations across drug class were reductions in N-acetylaspartate and elevations in myo-inositol, whereas changes in choline, creatine, and amino acid transmitters also were abundant. Together, the studies discussed herein provide evidence that drugs of abuse may have a profound effect on neuronal health, energy metabolism and maintenance, inflammatory processes, cell membrane turnover, and neurotransmission, and these biochemical changes may underlie the neuropathology within brain tissue that subsequently gives rise to the cognitive and behavioral impairments associated with drug addiction.

Indexed as

AlcoholismAnimalsAppetite StimulantsAspartic AcidBrainCholineCocaineCreatineGlutamic AcidHumansInositolMagnetic Resonance SpectroscopyMarijuana AbuseNeurochemistryOpiate AlkaloidsSmokingAppetite StimulantsAspartic AcidCholineCocaineCreatineGlutamic AcidInositolN-acetylaspartateOpiate AlkaloidsToluene

Identifiers

PMID20201852
PMCPMC3040110
OpenAlexW2113928639

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.