ArticleHippocampus2011
Kalirin-7, an important component of excitatory synapses, is regulated by estradiol in hippocampal neurons.
Article in Hippocampus, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 43 citations in OpenAlex.
- Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats.International journal of molecular sciences · 2023Article
- MDMA treatment paired with a trauma-cue promotes adaptive stress responses in a translational model of PTSD in rats.Translational psychiatry · 2022Article
- Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice.Frontiers in pharmacology · 2021Article
- Role of Kalirin and mouse strain in retention of spatial memory training in an Alzheimer's disease model mouse line.Neurobiology of aging · 2020Article
- Role of Cdk5 in Kalirin7-Mediated Formation of Dendritic Spines.Neurochemical research · 2019Article
- Kalirin-7 plays a neuroprotective role in Neuro-2A cells injured by oxygen-glucose deprivation and reperfusion through Rac1 activation.Iranian journal of basic medical sciences · 2018Article
- Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors.BMC neuroscience · 2017Article
- RhoGTPases at the synapse: An embarrassment of choice.Small GTPases · 2017Review
- Genetic Variant ofBioMed research international · 2017Article
- Exome sequencing discloses KALRN homozygous variant as likely cause of intellectual disability and short stature in a consanguineous pedigree.Human genomics · 2016Article
- Article
- Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Control of Dendritic Spine Morphological and Functional Plasticity by Small GTPases.Neural plasticity · 2016Review
- A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease.Human molecular genetics · 2015Article
- Estradiol pretreatment ameliorates impaired synaptic plasticity at synapses of insulted CA1 neurons after transient global ischemia.Brain research · 2015Article
- Reversing synapse loss in Alzheimer's disease: Rho-guanosine triphosphatases and insights from other brain disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Estradiol regulates large dense core vesicles in the hippocampus of adult female rats.Brain structure & function · 2014Article
- Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.Hormones and behavior · 2014Article
- Chronic exposure of mutant DISC1 mice to lead produces sex-dependent abnormalities consistent with schizophrenia and related mental disorders: a gene-environment interaction study.Schizophrenia bulletin · 2014Article
- Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.Molecular biology of the cell · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Estradiol enhances the formation of dendritic spines and excitatory synapses in hippocampal neurons in vitro and in vivo, but the underlying mechanisms are not fully understood. Kalirin-7 (Kal7), the major isoform of Kalirin in the adult hippocampus, is a Rho GDP/GTP exchange factor localized to postsynaptic densities. In the hippocampus, both Kal7 and estrogen receptor α (ERα) are highly expressed in a subset of interneurons. Over-expression of Kal7 caused an increase in spine density and size in hippocampal neurons. To determine whether Kalirin might play a role in the effects of estradiol on spine formation, Kal7 expression was examined in the hippocampus of ovariectomized rats. Estradiol replacement increased Kal7 staining in both CA1 pyramidal neurons and interneurons in ovariectomized rats. Estradiol treatment of cultured hippocampal neurons increased Kal7 levels at the postsynaptic side of excitatory synapses and increased the number of excitatory synapses along the dendrites of pyramidal neurons. These increases were mediated via ERα because a selective ERα agonist, but not a selective ERβ agonist, caused a similar increase in both Kal7 levels and excitatory synapse number in cultured hippocampal neurons. When Kal7 expression was reduced using a Kal7-specific shRNA, the density of excitatory synapses was reduced and estradiol was no longer able to increase synapse formation. Expression of exogenous Kal7 in hippocampal interneurons resulted in decreased levels of GAD65 staining. Inhibition of GABAergic transmission with bicuculline produced a robust increase in Kal7 expression. These studies suggest Kal7 plays a key role in the mechanisms of estradiol-mediated synaptic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.