ArticleMolecular biology reports2010
VEGF gene polymorphism association with diabetic neuropathy.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Genetics of diabetic neuropathy: Systematic review, meta-analysis and trial sequential analysis.Annals of clinical and translational neurology · 2019Pooled it
- VEGF genetic polymorphisms may contribute to the risk of diabetic nephropathy in patients with diabetes mellitus: a meta-analysis.TheScientificWorldJournal · 2014Pooled it
- Diabetic Peripheral Neuropathy in Children and Adolescents - Prevalence, Diagnostic Methods and Risk FactorsJournal of clinical research in pediatric endocrinology · 2026Review
- Genetic research in Immunogenetics Group of Endocrinology and Metabolism Research Institute.Journal of diabetes and metabolic disorders · 2024Review
- Article
- Advantages of omics approaches for elucidating metabolic changes in diabetic peripheral neuropathy.Frontiers in endocrinology · 2023Review
- Vascular Endothelial Growth Factor Single Nucleotide Polymorphism +405 G/C (rs2010963) is associated with Levels, Infection Severity, and Amputation among South Indian Diabetic Foot Ulcer Patients.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Clinical Implications ofCurrent issues in molecular biology · 2021Article
- Diabetic neuropathy in children and youth: New and emerging risk factors.Pediatric diabetes · 2021Review
- Endocrinology and Metabolism Research Institute from inception to maturity: an overview of 25-year activity.Journal of diabetes and metabolic disorders · 2020Article
- Advances with Long Non-Coding RNAs in Diabetic Peripheral Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Article
- Article
- The Role of Mitochondrial DNA (mtDNA) in the Development of Diabetic Retinopathy (DR): A Systematic Review.Medical hypothesis, discovery & innovation ophthalmology journal · 2017Review
- Association of VEGF and VEGFR1 polymorphisms with breast cancer risk in North Indians.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Association between VEGF -634G/C polymorphism and osteonecrosis of the femoral head susceptibility: a meta analysis.International journal of clinical and experimental medicine · 2015Article
- Relationship between single nucleotide polymorphisms in the 3'-untranslated region of the vascular endothelial growth factor gene and susceptibility to diabetic peripheral neuropathy in China.Archives of medical science : AMS · 2014Article
- Beneficial effect of TNF-α inhibition on diabetic peripheral neuropathy.Journal of neuroinflammation · 2013Article
- Association of single nucleotide polymorphisms in vascular endothelial growth factor gene with bladder cancer risk.Medical oncology (Northwood, London, England) · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular factors beside metabolic problems are involved in both etiopathogenesis of diabetic neuropathy, and more remarkably, later in "repair" phase, that governs the net balance between neuro-regenerative/degenerative reactions. Regarding ischemic nature of diabetic neuropathy that highlights necessity of blood vessels re-establishment during tissue healing, VEGF (vascular endothelial growth factor) has been recently the subject of extensive investigations in diabetic neuropathy (DNU). This growth factor possesses angiogenic potentials in addition to the hemodynamic functions. The distribution of VEGF gene polymorphisms at positions -7*C/T, -1001*G/C, -1154*G/A and -2578*C/A were analysed by ARMS-PCR in 248 type 1 diabetic British-Caucasian subjects (81 DNU+, 167 DNU-). We have found that distribution of a VEGF gene polymorphism at promoter region (-7*C/T) was significantly different between diabetic subjects with vs. without neuropathy and the allele (C) conferred susceptibility to DNU (P = 0.02; OR = 1.78, 95% CI 1.0-3.1). The present study indicates that polymorphism of the VEGF gene at position -7*C/T might be implicated in the pathogenesis of diabetic neuropathy as it may harbour some functional/regulatory potential in VEGF gene expression. However, this requires further studies in order to better understand its phenotypic impact and to investigate the prognostic value of this polymorphism in diabetic neuropathy as a chronic complication of diabetes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.