ReviewArthritis research & therapy2010
Genetic associations in type I interferon related pathways with autoimmunity.
Review in Arthritis research & therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Pharmacokinetics, Safety, and Tolerability of Single-Dose Dazukibart in Healthy Adults in China and Japan: Results From 2 Randomized, Double-Blind, Phase 1 Studies.Clinical pharmacology in drug development · 2025Trial
- Shared Genetic Susceptibility Between Asthma and Immune-Mediated Inflammatory Diseases.Canadian respiratory journal · 2026Article
- Integrating state-space modeling, parameter estimation, deep learning, and docking techniques in drug repurposing: a case study on COVID-19 cytokine storm.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Case report: Exploring efficacy of tofacitinib in modulating interferon response in five case of anti-MDA5+ dermatomyositis with interstitial lung disease.Frontiers in immunology · 2025Article
- Baricitinib therapy response in rheumatoid arthritis patients associates to STAT1 phosphorylation in monocytes.Frontiers in immunology · 2022Article
- Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature.Frontiers in immunology · 2021Review
- Dynamics of the Type I Interferon Response During Immunosuppressive Therapy in Rheumatoid Arthritis.Frontiers in immunology · 2019Article
- Immune response biomarkers in human and veterinary research.Comparative immunology, microbiology and infectious diseases · 2018Review
- MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients.Frontiers in physiology · 2017Article
- C1q-mediated repression of human monocytes is regulated by leukocyte-associated Ig-like receptor 1 (LAIR-1).Molecular medicine (Cambridge, Mass.) · 2015Article
- Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy.Cell reports · 2014Article
- Genetics of ANCA-associated Vasculitides.Current rheumatology reports · 2014Review
- Twins discordant for myositis and systemic lupus erythematosus show markedly enriched autoantibodies in the affected twin supporting environmental influences in pathogenesis.BMC musculoskeletal disorders · 2014Article
- The contribution of epigenetics in Sjögren's Syndrome.Frontiers in genetics · 2014Review
- Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1.PLoS pathogens · 2011Article
- A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus.PLoS genetics · 2011Article
- Genetics and genomics of Sjögren's syndrome: research provides clues to pathogenesis and novel therapies.Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
Type I interferons play an outstanding role in innate and adaptive immunity by enhancing functions of dendritic cells, inducing differentiation of monocytes, promoting immunoglobulin class switching in B cells and stimulating effector functions of T cells. The increased production of IFNα/β by plasmacytoid dendritic cells could be responsible for not only efficient antiviral defence, but it also may be a pathological factor in the development of various autoimmune disorders. The first evidence of a genetic link between type I interferons and autoimmune diseases was the observation that elevated IFNα activity is frequently detected in the sera of patients with systemic lupus erythematosus, and that this trait shows high heritability and familial aggregation in their first-degree healthy relatives. To date, a number of genes involved in interferon signalling have been associated with various autoimmune diseases. Patients with systemic lupus erythematosus, Sjögren's syndrome, dermatomyositis, psoriasis, and a fraction of patients with rheumatoid arthritis display a specific expression pattern of interferon-dependent genes in their leukocytes, termed the interferon signature. Here, in an attempt to understand the role of type I interferons in the pathogenesis of autoimmunity, we review the recent advances in the genetics of autoimmune diseases focusing on the association of genes involved in type I interferon pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.