Trial reportDiabetes2010
A prospective analysis of elevated fasting glucose levels and cognitive function in older people: results from PROSPER and the Rotterdam Study.
Trial report in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 85 citations in OpenAlex.
- Insulin and sex interactions in older adults with mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2012Trial
- Association of TyG index and obesity indicators with cognitive function: a cross - sectional study from Chinese health check-up centers.BMC endocrine disorders · 2026Article
- Cognitive function in normotensive elderly adults: a population-based cross-sectional study in rural China.Frontiers in medicine · 2026Article
- Association between estimated glucose disposal rate and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Evaluation of the glymphatic system using the DTI-ALPS index in type 2 diabetes mellitus-induced cognitive impairment.Journal of clinical imaging science · 2025Article
- Development of PPARγ Agonists for the Treatment of Neuroinflammatory and Neurodegenerative Diseases: Leriglitazone as a Promising Candidate.International journal of molecular sciences · 2023Review
- Application of Grey Relational Analysis to Predict Dementia Tendency by Cognitive Function, Sleep Disturbances, and Health Conditions of Diabetic Patients.Brain sciences · 2022Article
- Effects of raw red beetroot consumption on metabolic markers and cognitive function in type 2 diabetes patients.Journal of diabetes and metabolic disorders · 2021Article
- HbA1c and brain health across the entire glycaemic spectrum.Diabetes, obesity & metabolism · 2021Article
- Insulin sensitivity predicts cognitive decline in individuals with prediabetes.BMJ open diabetes research & care · 2020Article
- The Interplay between Diabetes and Alzheimer's Disease-In the Hunt for Biomarkers.International journal of molecular sciences · 2020Review
- Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study.Journal of epidemiology · 2020Article
- Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.Nature neuroscience · 2019Article
- Diabetes and Alzheimer's Disease: A Link not as Simple as it Seems.Neurochemical research · 2019Review
- Different risk factors for cognitive impairment among community-dwelling elderly, with impaired fasting glucose or diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Impact of glycemic status on longitudinal cognitive performance in men with and without HIV infection.AIDS (London, England) · 2018Article
- Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis.The Journal of biological chemistry · 2016Article
- Cognitive decline following incident and preexisting diabetes mellitus in a population sample.Neurology · 2016Article
- Aberrant functional connectivity of default-mode network in type 2 diabetes patients.European radiology · 2015Article
- The Rotterdam Study: 2016 objectives and design update.European journal of epidemiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between fasting glucose levels, insulin resistance, and cognitive impairment in old age. Diabetes is associated with cognitive impairment in older people. However, the link between elevated fasting glucose levels and insulin resistance in nondiabetic individuals, and the risk of cognitive impairment is unclear. RESEARCH DESIGN AND
methodsWe analyzed data from, in total, 8,447 participants in two independent prospective studies: the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), 5,019 participants, aged 69-84 years, and the Rotterdam Study, 3,428 participants, aged 61-97 years. Fasting glucose levels were assessed at baseline in both studies; fasting insulin levels were assessed in the Rotterdam Study only. Cognitive function was assessed in both studies at baseline and during follow-up.
resultsSubjects with diabetes had impaired cognitive function at baseline. In contrast, in people without a history of diabetes, there was no clear association between baseline fasting glucose levels and executive function and memory, nor was there a consistent relationship between elevated baseline fasting glucose levels and the rate of cognitive decline in either cohort. Insulin resistance (homeostasis model assessment index) was also unrelated to cognitive function and decline.
conclusionsElevated fasting glucose levels and insulin resistance are not associated with worse cognitive function in older people without a history of diabetes. These data suggest either that there is a threshold for effects of dysglycemia on cognitive function or that factors other than hyperglycemia contribute to cognitive impairment in individuals with frank diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.