ArticleThe Journal of cell biology2010
Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis.
Article in The Journal of cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers.
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Who cites it
180 citing papers in PubMed, 320 citations in OpenAlex.
- Trial
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- Chromosome condensation mechanically primes the nucleus for mitosis.The EMBO journal · 2026Article
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- Physiological and transcriptomic analyses reveal the effects of phytohormones on growth and astaxanthin accumulation in Haematococcus pluvialis.BMC plant biology · 2026Article
- Zebrafish otic vesicle and mouse epididymis as model systems for studying columnar epithelial cell division.Scientific reports · 2026Article
- A small molecule inhibitor of ARF GTPase protein 1 limits liver and colon cancer cell growth and metastasis.Cell death & disease · 2026Article
- Multi-omic analysis of human PHACTR1 signaling networks.Communications biology · 2026Article
- Physical Frameworks and Theories on How Autonomous Biological Oscillators Synchronize.Advances in experimental medicine and biology · 2026Review
- Setting Up to Divide: Nuclear Mechanotransduction in the Regulation of Mitosis.Results and problems in cell differentiation · 2026Review
- The Centriole Biogenesis Cycle: Temporal Mechanisms, Autonomy and Coupling to the Cell Cycle and Other Cellular Clocks.Advances in experimental medicine and biology · 2026Review
- Cell-APP: A generalizable method for cell annotation and cell-segmentation model training.Molecular biology of the cell · 2025Article
- Zebrafish otic vesicle and mouse epididymis as model systems for studying columnar epithelial cell division.bioRxiv : the preprint server for biology · 2025Article
- MCPIP3/Regnase-3 binds 14-3-3 proteins and contributes to the regulation of the cell cycle in human immortalized keratinocytes.Scientific reports · 2025Article
- A distinct phase of cyclin B (Cdc13) nuclear export at mitotic entry inOpen biology · 2025Article
- The cAMP-PKA signaling initiates mitosis by phosphorylating Bora.Nature communications · 2025Article
- Cell-APP: A generalizable method for cell annotation and cell-segmentation model training.bioRxiv : the preprint server for biology · 2025Article
- Article
120 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The cyclin B-Cdk1 kinase triggers mitosis in most eukaryotes. In animal cells, cyclin B shuttles between the nucleus and cytoplasm in interphase before rapidly accumulating in the nucleus at prophase, which promotes disassembly of the nuclear lamina and nuclear envelope breakdown (NEBD). What triggers the nuclear accumulation of cyclin B1 is presently unclear, although the prevailing view is that the Plk1 kinase inhibits its nuclear export. In this study, we use a biosensor specific for cyclin B1-Cdk1 activity to show that activating cyclin B1-Cdk1 immediately triggers its rapid accumulation in the nucleus through a 40-fold increase in nuclear import that remains dependent on Cdk1 activity until NEBD. Nevertheless, a substantial proportion of cyclin B1-Cdk1 remains in the cytoplasm. The increase in nuclear import is driven by changes in the nuclear import machinery that require neither Plk1 nor inhibition of nuclear export. Thus, the intrinsic link between cyclin B1-Cdk1 activation and its rapid nuclear import inherently coordinates the reorganization of the nucleus and the cytoplasm at mitotic entry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.