ArticleFrontiers in molecular neuroscience2010
Altered Organization of GABA(A) Receptor mRNA Expression in the Depressed Suicide Brain.
Article in Frontiers in molecular neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Molecular Mechanisms of Menstrual Cycle-Related Suicide Risk: A Selective Review of Promising Candidate Systems.Biological psychiatry · 2026Review
- Eukaryotic initiation factor 4E: a key factor of traumatic stress-induced depression-related cognitive decline at different age.Translational psychiatry · 2026Article
- The association between gamma-aminobutyric acid levels and suicidal behavior in depression.BMC psychiatry · 2025Article
- Maternal separation and its developmental consequences on anxiety and parvalbumin interneurons in the amygdala.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABAScientific reports · 2021Article
- Review
- Modeling endophenotypes of suicidal behavior in animals.Neuroscience and biobehavioral reviews · 2021Review
- Differential Dorsolateral Prefrontal Cortex Proteomic Profiles of Suicide Victims with Mood Disorders.Genes · 2020Article
- Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies.Molecular psychiatry · 2020Review
- GABAFrontiers in neuroscience · 2020Article
- Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness.Frontiers in neural circuits · 2018Review
- A new stress sensor and risk factor for suicide: the T allele of the functional genetic variant in the GABRA6 gene.Scientific reports · 2017Article
- Neuropathology of suicide: recent findings and future directions.Molecular psychiatry · 2017Review
- Altered miRNA expression network in locus coeruleus of depressed suicide subjects.Scientific reports · 2017Article
- The Life Span Model of Suicide and Its Neurobiological Foundation.Frontiers in neuroscience · 2017Article
- Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.Neuroscience · 2016Article
- Suicide attempters with Borderline Personality Disorder show differential orbitofrontal and parietal recruitment when reflecting on aversive memories.Journal of psychiatric research · 2016Article
- Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy.Epilepsy & behavior : E&B · 2015Article
- Altered expression of neuroplasticity-related genes in the brain of depressed suicides.Neuroscience · 2015Article
- An overview of the neurobiology of suicidal behaviors as one meta-system.Molecular psychiatry · 2015Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inter-relationships ordinarily exist between mRNA expression of GABA(A) subunits in the frontopolar cortex (FPC) of individuals that had died suddenly from causes other than suicide. However, these correlations were largely absent in persons that had died by suicide. In the present investigation, these findings were extended by examining GABA(A) receptor expression patterns (of controls and depressed individuals that died by suicide) in the orbital frontal cortex (OFC), hippocampus, amygdala. locus coeruleus (LC) and paraventricular nucleus (PVN), all of which have been implicated in either depression, anxiety or stress responsivity. Using QPCR analysis, we found that in controls the inter-relations between GABA(A) subunits varied across brain regions, being high in the hippocampus and amygdala, intermediate in the LC, and low in the OFC and PVN. The GABA(A) subunit inter-relations were markedly different in persons that died by suicide, being reduced in hippocampus and amygdala, stable in the LC, but more coordinated in the OFC and to some extent in the PVN. It seems that altered brain region-specific inhibitory signaling, stemming from altered GABA(A) subunit coordination, are associated with depression/suicide. Although, it is unknown whether GABA(A) subunit re-organization was specifically tied to depression, suicide, or the accompanying distress, these data show that the coordinated expression of this transcriptome does vary depending on brain region and is plastic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.