Evidence map›Paper›PMID 20423700›Full record

ArticleBrain research2010

Processing of food pictures: influence of hunger, gender and calorie content.

Sabine Frank, Naima Laharnar, Stephanie Kullmann, Ralf Veit, Carlos Canova, Yiwen Li Hegner, Andreas Fritsche, Hubert Preissl

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03361098 (Combined Effects of SGLT2 Inhibition and GLP-1 Receptor Agonism on Food Intake, Body Weight and Central Satiety and Reward Circuits in Obese T2DM Patients), which is not on this map. Cited by 127 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 1 pooled it
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03361098 phase4completedstarted 2017, after this paper: background citation

Combined Effects of SGLT2 Inhibition and GLP-1 Receptor Agonism on Food Intake, Body Weight and Central Satiety and Reward Circuits in Obese T2DM Patients

Ran2017Enrolled65Registered outcomes18Posted comparisons0ConditionsObesity, Type 2 Diabetes MellitusArmsDapagliflozin 10mg, exenatide, placebo dapagliflozin, placebo exenatide
PMID 26769912PMID 27651331PMID 24463454PMID 28869249PMID 28345814PMID 26815786PMID 26672638PMID 26403227PMID 26385462PMID 26331843PMID 26180105PMID 26094857other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 1 synthesis or guideline pooled it, 298 citations in OpenAlex.

  1. Sex/gender differences in neural correlates of food stimuli: a systematic review of functional neuroimaging studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Sabine FrankMEG-Center, University of Tübingen, Tübingen, Germany. sabine.frank@med.uni-tuebingen.de
Naima Laharnar
Stephanie Kullmann
Ralf Veit
Carlos Canova
Yiwen Li Hegner
Andreas Fritsche
Hubert Preissl
University of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In most cases obesity, a major risk factor for diabetes mellitus type 2 and other associated chronic diseases, is generated by excessive eating. For a better understanding of eating behavior, it is necessary to determine how it is modulated by factors such as the calorie content of food, satiety and gender. Twelve healthy normal weighted participants (six female) were investigated in a functional magnetic resonance imaging (fMRI) study. In order to prevent the influence of social acceptability, an implicit one-back task was chosen for stimulus presentation. We presented food (high- and low-caloric) and non-food pictures in a block design and subjects had to indicate by button press whether two consecutive pictures were the same or not. Each subject performed the task in a hungry and satiated state on two different days. High-caloric pictures compared to low-caloric pictures led to increased activity in food processing and reward related areas, like the orbitofrontal and the insular cortex. In addition, we found activation differences in visual areas (occipital lobe), despite the fact that the stimuli were matched for their physical features. Detailed investigation also revealed gender specific effects in the fusiform gyrus. Women showed higher activation in the fusiform gyrus while viewing high-caloric pictures in the hungry state. This study shows that the calorie content of food pictures modulates the activation of brain areas related to reward processing and even early visual areas. In addition, satiation seems to influence the processing of food pictures differently in men and women. Even though an implicit task was used, activation differences could also be observed in the orbitofrontal cortex, known to be activated during explicit stimulation with food related stimuli.

Indexed as

FoodAdultBrainBrain MappingCuesFemaleHumansHungerImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePhotic StimulationReaction TimeRewardSatiationSex Factors

Identifiers

PMID20423700
OpenAlexW2005148500

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.