ReviewJournal of biomedicine & biotechnology2010
Pathogenesis of insulin resistance in skeletal muscle.
Review in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 326 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy/Safety Study of Adding Glimepiride to Type 2 Diabetes Patients With Inadequate Glycemic Control Based on Combination With Metformin And Basal Insulin
Open the trial in the graphEthnic Dependence of the Metabolic Defects in Prediabetic Individuals: Kuwaiti Arabs Versus Indians
Who cites it
326 citing papers in PubMed, 4 syntheses or guidelines pooled it, 648 citations in OpenAlex.
- Effectiveness of Resistance Training and Associated Program Characteristics in Patients at Risk for Type 2 Diabetes: a Systematic Review and Meta-analysis.Sports medicine - open · 2021Pooled it
- Antipsychotic Medications and DNA Methylation in Schizophrenia and Bipolar Disorder: A Systematic Review.Pharmacotherapy · 2020Pooled it
- Insulin resistance induced by olanzapine and other second-generation antipsychotics in Chinese patients with schizophrenia: a comparative review and meta-analysis.European journal of clinical pharmacology · 2019Pooled it
- The Effect of Low-Volume High-Intensity Interval Training on Body Composition and Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2019Pooled it
- Trial
- The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study.Obesity (Silver Spring, Md.) · 2026Trial
- Trial
- Amino Acid-Stimulated Muscle Protein Synthesis is Attenuated During Early Recovery from Aerobic Exercise in Individuals with Obesity.bioRxiv : the preprint server for biology · 2026Article
- Heat Shock Proteins and Exercise in Skeletal Muscle Insulin Resistance: Protective Mechanisms and Therapeutic Potential.International journal of molecular sciences · 2026Review
- A Novel Blend ofFoods (Basel, Switzerland) · 2026Article
- Interplay between sarcopenia and type 2 diabetes: mechanisms, implications, and therapeutic prospects.Nutrition & diabetes · 2026Review
- Sustained moderate to high triglyceride-glucose index level is associated with a lower risk of sarcopenia in middle-aged and elderly adults: a nationally representative cohort study.Lipids in health and disease · 2026Article
- Estrogen Deprivation During Primate (Papio anubis) Pregnancy: Impact on Systemic Microvascular Flow and Cardiovascular Development and Function After Birth in Offspring.Journal of medical primatology · 2026Article
- Differential associations of diet with hepatic and muscle insulin resistance: insights from an dietary pattern analysis in the PERSON study.European journal of nutrition · 2026Observational
- Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate the Severity of Obesity-Associated White Adipose Tissue and Skeletal Muscle Dysfunction.Marine drugs · 2026Review
- Review
- Integrative single-cell RNA-seq and ATAC-seq profiling identifies NTN5Zoological research · 2026Article
- Selenoprotein N and SEPN1-Related Myopathies: Mechanisms, Models, and Therapeutic Perspectives.Biomolecules · 2026Review
- Lymphatic dysfunction and impaired interstitial clearance in sarcopenic obesity: a hypothesis-generating review.Frontiers in endocrinology · 2026Review
- Association between creatinine-to-body weight ratio and incident prediabetes in Chinese adults: a large-scale retrospective cohort study.Frontiers in endocrinology · 2026Article
266 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance in skeletal muscle is manifested by decreased insulin-stimulated glucose uptake and results from impaired insulin signaling and multiple post-receptor intracellular defects including impaired glucose transport, glucose phosphorylation, and reduced glucose oxidation and glycogen synthesis. Insulin resistance is a core defect in type 2 diabetes, it is also associated with obesity and the metabolic syndrome. Dysregulation of fatty acid metabolism plays a pivotal role in the pathogenesis of insulin resistance in skeletal muscle. Recent studies have reported a mitochondrial defect in oxidative phosphorylation in skeletal muscle in variety of insulin resistant states. In this review, we summarize the cellular and molecular defects that contribute to the development of insulin resistance in skeletal muscle.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.