ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2010
Radionuclide imaging of cardiac autonomic innervation.
Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Cardiac Autonomic Neuropathy in Diabetes Mellitus: Pathogenesis, Epidemiology, Diagnosis and Clinical Implications: A Narrative Review.Journal of clinical medicine · 2025Review
- Neurohumoral Markers of Cardiac Autonomic Denervation after Surgical Ablation of Long-Standing Persistent Atrial Fibrillation.Life (Basel, Switzerland) · 2023Article
- Article
- Relationship between the washout rate of I-123 MIBG scans and autonomic function in Parkinson's disease.PloS one · 2020Article
- Anthracycline-induced cardiomyopathy: The search continues.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- The natural history of takotsubo syndrome: a two-year follow-up study with myocardial sympathetic and perfusion G-SPECT imaging.European journal of nuclear medicine and molecular imaging · 2017Article
- Imaging for assessment of sudden death risk: current role and future prospects.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2016Review
- Cardiac sympathetic hyperactivity after chemotherapy: early sign of cardiotoxicity?Arquivos brasileiros de cardiologia · 2015Article
- Diagnostic and prognostic utility of non-invasive imaging in diabetes management.World journal of diabetes · 2015Review
- Pulmonary vein isolation in patients with paroxysmal atrial fibrillation is associated with regional cardiac sympathetic denervation.EJNMMI research · 2013Article
- Reduced cardiac 123I-metaiodobenzylguanidine uptake in patients with spinocerebellar ataxia type 2: a comparative study with Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2013Article
- Cardiac autonomic imaging with SPECT tracers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- A key role for nuclear cardiac imaging in evaluating and managing patients with heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Assessment of global cardiac I-123 MIBG uptake and washout using volumetric quantification of SPECT acquisitions.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Recent insights into the role of the autonomic nervous system in the creation of substrate for atrial fibrillation: implications for therapies targeting the atrial autonomic nervous system.Circulation. Arrhythmia and electrophysiology · 2012Review
- Use of cardiac radionuclide imaging to identify patients at risk for arrhythmic sudden cardiac death.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac autonomic function plays a crucial role in health and disease, with abnormalities both reflecting the severity of the disease and contributing specifically to clinical deterioration and poor prognosis. Radiotracer analogs of the sympathetic mediator norepinephrine have been investigated extensively, and are at the brink of potential widespread clinical use. The most widely studied SPECT tracer, I-123 metaiodobenzylguanidine ((123)I-mIBG) has consistently shown a strong, independent ability to risk stratify patients with advanced congestive heart failure. Increased global cardiac uptake appears to have a high negative predictive value in terms of cardiac events, especially death and arrhythmias, and therefore and may have a role in guiding therapy, particularly by helping to better select patients unresponsive to conventional medical therapies who would benefit from device therapies such as an ICD (implantable cardioverter defibrillator), CRT (cardiac resynchronization therapy), LVAD (left ventricular assist device), or cardiac transplantation. Cardiac autonomic imaging with SPECT and PET tracers also shows potential to assess patients following cardiac transplant, those with primary arrhythmic condition, coronary artery disease, diabetes mellitus, and during cardiotoxic chemotherapy. Radiotracer imaging of cardiac autonomic function allows visualization and quantitative measurements of underlying molecular aspects of cardiac disease, and should therefore provide a perspective that other cardiac tests cannot.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.