ReviewNeuroscience and biobehavioral reviews2010
The effects of cholesterol on learning and memory.
Review in Neuroscience and biobehavioral reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Status of nutrients important in brain function in phenylketonuria: a systematic review and meta-analysis.Orphanet journal of rare diseases · 2018Pooled it
- The orientation of cholesterol's hydroxy group affects its membrane dynamics and intracellular transport.iScience · 2026Article
- Nutrition, Cognition and Learning: The Role of White Matter Development and Connectivity.medRxiv : the preprint server for health sciences · 2026Article
- Low 5HTJournal of neurochemistry · 2026Review
- The orientation of cholesterol's hydroxyl group affects its membrane dynamics and intracellular transport.bioRxiv : the preprint server for biology · 2026Article
- Cholesterol depletion inhibits BDNF-dependent spike timing-dependent plasticity at thalamo-amygdala synapses.Frontiers in cellular neuroscience · 2026Article
- Genetic Mapping of Behavioral Traits Using the Collaborative Cross Resource.International journal of molecular sciences · 2022Article
- Food Restriction Counteracts Dexamethasone-Induced Downregulation of Genes Involved in Cholesterol Homeostasis in Rat Brain during Aging.Brain sciences · 2022Article
- Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.Frontiers in genetics · 2022Article
- Exercise Effects on Cognition in Older African Americans: A Pilot Randomized Trial.Frontiers in aging neuroscience · 2022Article
- Long-Term Levels of LDL-C and Cognitive Function: The CARDIA Study.Journal of the International Neuropsychological Society : JINS · 2021Article
- Treadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats.International neurourology journal · 2021Article
- The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Review
- Lipid metabolic dysregulation is involved in Parkinson's disease dementia.Metabolic brain disease · 2021Article
- Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice.Molecular brain · 2021Article
- Influence of Dietary Nutrient Intake on Episodic Memory Across the Adult Life Span.Frontiers in aging neuroscience · 2021Article
- Dietary fibre and the gut-brain axis: microbiota-dependent and independent mechanisms of action.Gut microbiome (Cambridge, England) · 2021Review
- A practical application of generative adversarial networks for RNA-seq analysis to predict the molecular progress of Alzheimer's disease.PLoS computational biology · 2020Article
- Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Outcome age-based prediction of successful cognitive aging by total cholesterol.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cholesterol is vital to normal brain function including learning and memory but that involvement is as complex as the synthesis, metabolism and excretion of cholesterol itself. Dietary cholesterol influences learning tasks from water maze to fear conditioning even though cholesterol does not cross the blood brain barrier. Excess cholesterol has many consequences including peripheral pathology that can signal brain via cholesterol metabolites, pro-inflammatory mediators and antioxidant processes. Manipulations of cholesterol within the central nervous system through genetic, pharmacological, or metabolic means circumvent the blood brain barrier and affect learning and memory but often in animals already otherwise compromised. The human literature is no less complex. Cholesterol reduction using statins improves memory in some cases but not others. There is also controversy over statin use to alleviate memory problems in Alzheimer's disease. Correlations of cholesterol and cognitive function are mixed and association studies find some genetic polymorphisms are related to cognitive function but others are not. In sum, the field is in flux with a number of seemingly contradictory results and many complexities. Nevertheless, understanding cholesterol effects on learning and memory is too important to ignore.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.