ArticleInvestigative ophthalmology & visual science2010
Multifocal ERG defects associated with insufficient long-term glycemic control in adolescents with type 1 diabetes.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Precision Medicine for Diabetic Retinopathy: Integrating Genetics, Biomarkers, Lifestyle, and AI.Genes · 2025Review
- Early detection of retinal dysfunction in type 1 diabetes without retinopathy using multifocal electroretinography.Scientific reports · 2025Observational
- Contrast sensitivity function under three light conditions in patients with type 1 diabetes mellitus without retinopathy: a cross-sectional, case-control study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Serum glial fibrillary acidic protein and neurofilament light chain as biomarkers of retinal neurodysfunction in early diabetic retinopathy: results of the EUROCONDOR study.Acta diabetologica · 2023Article
- AMPLITUDE LOSS OF THE HIGH-FREQUENCY FLICKER ELECTRORETINOGRAM IN EARLY DIABETIC RETINOPATHY.Retina (Philadelphia, Pa.) · 2019Article
- Retinal Neurodegeneration as an Early Manifestation of Diabetic Eye Disease and Potential Neuroprotective Therapies.Current diabetes reports · 2019Review
- Loss of CD40 attenuates experimental diabetes-induced retinal inflammation but does not protect mice from electroretinogram defects.Visual neuroscience · 2017Article
- Neuroprotection as a Therapeutic Target for Diabetic Retinopathy.Journal of diabetes research · 2016Review
- Early retinal pigment epithelium dysfunction is concomitant with hyperglycemia in mouse models of type 1 and type 2 diabetes.Journal of neurophysiology · 2015Article
- Role of Electrophysiology in the Early Diagnosis and Follow-Up of Diabetic Retinopathy.Journal of diabetes research · 2015Review
- Multifocal electroretinography in diabetic retinopathy and diabetic macular edema.Current diabetes reports · 2014Review
- Endothelial progenitor cells in diabetic retinopathy.Frontiers in endocrinology · 2014Review
- Current trends in the monitoring and treatment of diabetic retinopathy in young adults.Mediators of inflammation · 2014Review
- Association between local neuroretinal function and control of adolescent type 1 diabetes.Investigative ophthalmology & visual science · 2012Article
- Analysis of multifocal electroretinograms from a population with type 1 diabetes using partial least squares reveals spatial and temporal distribution of changes to retinal function.Documenta ophthalmologica. Advances in ophthalmology · 2012Article
- Comparison of aqueous humor cytokine and chemokine levels in diabetic patients with and without retinopathy.Molecular vision · 2012Article
- Current approaches to the management of diabetic retinopathy and diabetic macular oedema.Drugs · 2010Review
- Clinical electroretinography in diabetic retinopathy: a review.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo investigate the relationship between long-term glycemic control and localized neuroretinal function in adolescents with type 1 diabetes (T1D) without diabetic retinopathy (DR).
methodsStandard (103 hexagons) and slow-flash (61 hexagons) multifocal ERGs (standard mfERG and sf mfERG) were recorded in 48 patients and 45 control subjects. Hexagons with delayed responses were identified as abnormal. Negative binomial regression analysis was conducted with the number of abnormal hexagons as the outcome variable. Glycated hemoglobin (HbA(1c)) levels, time since diagnosis of T1D, age at diagnosis of T1D, age at testing, and sex were the covariates. Another model replacing HbA(1c) closest to the date of testing with a 1-year average was also generated.
resultsThere were more abnormal hexagons for mfOPs in patients than in control subjects (P = 0.005). There was no significant difference in the mean number of abnormal hexagons for standard mfERG responses between patients and control subjects (P = 0.11). Negative binomial regression analysis for the standard mfERG data demonstrated that a 1-unit increase in HbA(1c) was associated with an 80% increase in the number of abnormal hexagons (P = 0.002), when controlling for age at testing. Analysis using the 1-year HbA(1c) averages did not result in significant findings.
conclusionsPoor long-term glycemic control is associated with an increase in areas of localized neuroretinal dysfunction in adolescents with T1D and no clinically visible DR. Stricter glucose control during the early stages of the disease may prevent neuroretinal dysfunction in this cohort.
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