ArticleThe Journal of comparative neurology2010
Roles for gamma-aminobutyric acid in the development of the paraventricular nucleus of the hypothalamus.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Reproductive steroid receptors and actions in the locus coeruleus of male macaques: Part of an aggression circuit?Progress in neuro-psychopharmacology & biological psychiatry · 2016Trial
- Prenatal stress alters offspring neurovascular, autonomic, and immune development in animal models of neuropsychiatric and cardiometabolic disorders.Journal of neuroendocrinology · 2026Review
- Neural response to stress differs by sex in young adulthood.Psychiatry research. Neuroimaging · 2023Article
- Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.Biological psychiatry · 2022Article
- Estrogen receptor alpha, G-protein coupled estrogen receptor 1, and aromatase: Developmental, sex, and region-specific differences across the rat caudate-putamen, nucleus accumbens core and shell.The Journal of comparative neurology · 2021Article
- A sexually dimorphic distribution of corticotropin-releasing factor receptor 1 in the paraventricular hypothalamus.Neuroscience · 2019Article
- Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Distribution and chemical composition of estrogen receptor β neurons in the paraventricular nucleus of the female and male mouse hypothalamus.The Journal of comparative neurology · 2017Article
- Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome.Dialogues in clinical neuroscience · 2016Review
- Sex and age differences in brain-derived neurotrophic factor and vimentin in the zebra finch song system: Relationships to newly generated cells.The Journal of comparative neurology · 2016Article
- Sex differences, hormones, and fMRI stress response circuitry deficits in psychoses.Psychiatry research · 2015Article
- Fetal hormonal programming of sex differences in depression: linking women's mental health with sex differences in the brain across the lifespan.Frontiers in neuroscience · 2014Article
- Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease.Frontiers in neuroendocrinology · 2014Review
- Article
- Cell death atlas of the postnatal mouse ventral forebrain and hypothalamus: effects of age and sex.The Journal of comparative neurology · 2013Article
- Sex-dependent pathophysiology as predictors of comorbidity of major depressive disorder and cardiovascular disease.Pflugers Archiv : European journal of physiology · 2013Review
- Volumetric parcellation methodology of the human hypothalamus in neuroimaging: normative data and sex differences.NeuroImage · 2013Article
- BDNF and the central control of feeding: accidental bystander or essential player?Trends in neurosciences · 2013Review
- Hypothalamic expression of snoRNA Snord116 is consistent with a link to the hyperphagia and obesity symptoms of Prader-Willi syndrome.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2012Article
- Hormonal programming across the lifespan.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The development of the hypothalamic paraventricular nucleus (PVN) involves several factors that work together to establish a cell group that regulates neuroendocrine functions and behaviors. Several molecular markers were noted within the developing PVN, including estrogen receptors (ER), neuronal nitric oxide synthase (nNOS), and brain-derived neurotrophic factor (BDNF). By contrast, immunoreactive gamma-aminobutyric acid (GABA) was found in cells and fibers surrounding the PVN. Two animal models were used to test the hypothesis that GABA works through GABA(A) and GABA(B) receptors to influence the development of the PVN. Treatment with bicuculline to decrease GABA(A) receptor signaling from embryonic day (E) 10 to E17 resulted in fewer cells containing immunoreactive (ir) ERalpha in the region of the PVN vs. control. GABA(B)R1 receptor subunit knockout mice were used to examine the PVN at P0 without GABA(B) signaling. In female but not male GABA(B)R1 subunit knockout mice, the positions of cells containing ir ERalpha shifted from medial to lateral compared with wild-type controls, whereas the total number of ir ERalpha-containing cells was unchanged. In E17 knockout mice, ir nNOS cells and fibers were spread over a greater area. There was also a significant decrease in ir BDNF in the knockout mice in a region-dependent manner. Changes in cell position and protein expression subsequent to disruption of GABA signaling may be due, in part, to changes in nNOS and BDNF signaling. Based on the current study, the PVN can be added as another site where GABA exerts morphogenetic actions in development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.