Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2010
The effect of increased genioglossus activity and end-expiratory lung volume on pharyngeal collapse.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05210998 (Investigation of the Effects of Respiratory Muscle Training Combined With Aerobic Exercise in Persons With Obstructive Sleep Apnea Syndrome), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Effects of Respiratory Muscle Training Combined With Aerobic Exercise in Persons With Obstructive Sleep Apnea Syndrome
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Anatomical determinants of upper airway collapsibility in obstructive sleep apnea: A systematic review and meta-analysis.Sleep medicine reviews · 2023Pooled it
- Effects of respiratory muscle therapy on obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Pooled it
- Atomoxetine plus oxybutynin for symptomatic snoring and airflow limitation in individuals without moderate-to-severe obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Trial
- Effect of lung function on the apnea-hypopnea index in patients with overlap syndrome: a multicenter cross-sectional study.Sleep & breathing = Schlaf & Atmung · 2020Trial
- Effect of 4-Aminopyridine on Genioglossus Muscle Activity during Sleep in Healthy Adults.Annals of the American Thoracic Society · 2017Trial
- Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation.The European respiratory journal · 2016Trial
- Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility during Non-REM Sleep in Healthy Subjects.American journal of respiratory and critical care medicine · 2016Trial
- The effect of tongue strength and endurance in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2026Article
- Review of Neurostimulation Therapies for Obstructive Sleep Apnea: Hypoglossal Nerve Stimulation and Beyond.Journal of clinical medicine · 2025Review
- Analysis of cervical tracheal characteristics of obstructive sleep apnoea-hypopnoea syndrome patients using ultrasound.Frontiers in medicine · 2025Article
- Endotypic Trait Differences in Class 2/3 Obese Patients with and without Obstructive Sleep Apnea: A Preliminary Analysis of Preoperative Bariatric Surgery Patients.Annals of the American Thoracic Society · 2024Article
- Loop Gain as a Predictor of Blood Pressure Response in Patients Treated for Obstructive Sleep Apnea: Secondary Analysis of a Clinical Trial.Annals of the American Thoracic Society · 2024Article
- Tongue Strength Training Increases Daytime Upper Airway Stability in Rats.Nature and science of sleep · 2021Article
- Respiratory-related displacement of the trachea in obstructive sleep apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Sleep quality in survivors of critical illness.Sleep & breathing = Schlaf & Atmung · 2019Article
- Neural memory of the genioglossus muscle during sleep is stage-dependent in healthy subjects and obstructive sleep apnoea patients.The Journal of physiology · 2018Article
- Understanding Pathophysiological Concepts Leading to Obstructive Apnea.Obesity surgery · 2018Review
- Article
- Hypoglossal motoneurons are endogenously activated by serotonin during the active period of circadian cycle.Respiratory physiology & neurobiology · 2018Article
- Obstructive sleep apnea: current perspectives.Nature and science of sleep · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Increasing either genioglossus muscle activity (GG) or end-expiratory lung volume (EELV) improves airway patency but not sufficiently for adequate treatment of obstructive sleep apnea (OSA) in most patients. The mechanisms by which these variables alter airway collapsibility likely differ, with increased GG causing airway dilation, whereas increased EELV may stiffen the airway walls through caudal traction. We sought to determine whether the airway stabilizing effect of GG activation is enhanced when EELV is increased. To investigate this aim, 15 continuous positive airway pressure (CPAP)-treated OSA patients were instrumented with an epiglottic catheter, intramuscular GG-EMG electrodes, magnetometers, and a nasal mask/pneumotachograph. Subjects slept supine in a sealed, head-out plastic chamber in which the extra-thoracic pressure could be lowered (to raise EELV) while on nasal CPAP with a variable deadspace to allow CO(2) stimulation (and GG activation). The pharyngeal critical closing pressure (P(CRIT)) was measured by sudden reduction of CPAP for three to five breaths each minute during non-rapid eye movement (NREM) sleep in 4 conditions: a) baseline, b) 500 ml increased EELV, c) 50% increased GG, and d) conditions b and c combined. P(CRIT) was found to be reduced from 2.2 + or - 0.7 cmH(2)O at baseline to -1.0 + or - 0.5 with increased EELV, 0.6 + or - 0.7 with increased GG and -1.6 + or - 0.7 when both variables were raised (P < 0.001). The slope of the P(CRIT) curves remained unchanged in all conditions (P = 0.05). However, the CPAP level at which flow limitation developed was lower in both increased EELV conditions (P = 0.001). These findings indicate that while both increased GG and EELV improve airway collapsibility, the combination of both variables has little additional effect over increasing EELV alone.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.