ArticleAmerican journal of epidemiology2010
Differential associations of weight dynamics with coronary artery calcium versus common carotid artery intima-media thickness: The CARDIA Study.
Article in American journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Association of osteocalcin with obesity, insulin resistance, and cardiovascular risk factors in young adults.Obesity (Silver Spring, Md.) · 2012Trial
- Long-Term Body Mass Index Variability and Adverse Cardiovascular Outcomes.JAMA network open · 2024Article
- Association Between Weight Change and Increased Likelihood of Abdominal Aortic Calcification Among Men.Journal of the Endocrine Society · 2022Article
- Association of weight fluctuation with cardiovascular disease risk among initially obese adults.Scientific reports · 2021Article
- Body mass index trajectories during mid to late life and risks of mortality and cardiovascular outcomes: Results from four prospective cohorts.EClinicalMedicine · 2021Article
- Variabilities in Weight and Waist Circumference and Risk of Myocardial Infarction, Stroke, and Mortality: A Nationwide Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2020Article
- Weight cycling is associated with adverse cardiometabolic markers in a cross-sectional representative US sample.Journal of epidemiology and community health · 2020Article
- Impact of weight variability on mortality among Korean men and women: a population based study.Scientific reports · 2019Article
- Where are they now? Retention strategies over 25 years in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.Contemporary clinical trials communications · 2018Article
- Impact of weight cycling on risk of morbidity and mortality.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2014Review
- Healthy lifestyle change and subclinical atherosclerosis in young adults: Coronary Artery Risk Development in Young Adults (CARDIA) study.Circulation · 2014Article
- Coronary artery calcification is inversely related to body morphology in patients with significant coronary artery disease: a three-dimensional intravascular ultrasound study.European heart journal. Cardiovascular Imaging · 2014Article
- Atherosclerosis burden in patients with acute chest pain: obesity paradox.ISRN obesity · 2014Article
- A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and U.S. whites.European heart journal. Cardiovascular Imaging · 2013Article
- Fasting glucose, obesity, and coronary artery calcification in community-based people without diabetes.Diabetes care · 2012Article
- Inverse relationship between body mass index and coronary artery calcification in patients with clinically significant coronary lesions.Atherosclerosis · 2012Article
- Factors associated with development of prolonged QRS duration over 20 years in healthy young adults: the Coronary Artery Risk Development in Young Adults study.Journal of electrocardiology · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Change and fluctuation in body mass index (BMI; weight (kg)/height (m)(2)) may be associated differently with coronary artery calcification (CAC) than with carotid artery intima-media thickness (IMT). The authors analyzed data on 2,243 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, initially aged 18-30 years, who were examined every 2-5 years over a 20-year period (1985-2006). BMI at year 0 was associated positively and linearly with CAC at year 20; however, the association of BMI with year 20 CAC became progressively U-shaped in subsequent examinations (years 10, 15, and 20). To understand the deepening U shape, the authors modeled year 20 BMI and its history using 3 indices: year 0 BMI, linear slope of BMI during 20 years, and BMI fluctuation during 20 years. In models including these 3 terms, year 0 BMI was associated positively with CAC, as was BMI fluctuation. However, adjusted odds ratios across quintiles of BMI slope (vs. the lowest quintile) were 0.7, 0.4, 0.5, and 0.4 (P(trend) < 0.01), suggesting higher risk of CAC with weight loss, plateauing after moderate weight gain. In contrast, IMT was associated positively with BMI at all examinations and with 20-year BMI slope and was unassociated with BMI fluctuation. Surprisingly, CAC risk was higher with BMI loss and lower with BMI gain, whereas associations with IMT were as expected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.