ArticlePloS one2010
Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
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- Repeat length of C9orf72-associated glycine-alanine polypeptides affects their toxicity.Acta neuropathologica communications · 2023Article
- The biosynthetic-secretory pathway, supplemented by recycling routes, determines epithelial membrane polarity.Science advances · 2023Article
- Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea.iScience · 2023Article
- The Osiris family genes function as novel regulators of the tube maturation process in the Drosophila trachea.PLoS genetics · 2023Article
- Mesenchymal-to-epithelial transitions require tissue-specific interactions with distinct laminins.The Journal of cell biology · 2021Article
- Temporal specificity and heterogeneity of Drosophila immune cells.The EMBO journal · 2020Article
- Article
- Development and Function of theGenetics · 2018Review
- Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- "Salivary gland cellular architecture in the Asian malaria vector mosquito Anopheles stephensi".Parasites & vectors · 2015Article
- Cortical instability drives periodic supracellular actin pattern formation in epithelial tubes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export.Traffic (Copenhagen, Denmark) · 2015Article
- A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation.eLife · 2014Article
- The novel Smad protein Expansion regulates the receptor tyrosine kinase pathway to control Drosophila tracheal tube size.Developmental biology · 2014Article
- Trafficking mechanisms of extracellular matrix macromolecules: insights from vertebrate development and human diseases.The international journal of biochemistry & cell biology · 2014Review
- Novel mechanisms of tube-size regulation revealed by the Drosophila trachea.Cell and tissue research · 2013Review
- Worming our way in and out of the Caenorhabditis elegans germline and developing embryo.Traffic (Copenhagen, Denmark) · 2013Review
- Control of airway tube diameter and integrity by secreted chitin-binding proteins in Drosophila.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe differentiation of an extracellular matrix (ECM) at the apical side of epithelial cells implies massive polarised secretion and membrane trafficking. An epithelial cell is hence engaged in coordinating secretion and cell polarity for a correct and efficient ECM formation. PRINCIPAL
findingsWe are studying the molecular mechanisms that Drosophila tracheal and epidermal cells deploy to form their specific apical ECM during differentiation. In this work we demonstrate that the two genetically identified factors haunted and ghost are essential for polarity maintenance, membrane topology as well as for secretion of the tracheal luminal matrix and the cuticle. We show that they code for the Drosophila COPII vesicle-coating components Sec23 and Sec24, respectively, that organise vesicle transport from the ER to the Golgi apparatus.
conclusionTaken together, epithelial differentiation during Drosophila embryogenesis is a concerted action of ECM formation, plasma membrane remodelling and maintenance of cell polarity that all three rely mainly, if not absolutely, on the canonical secretory pathway from the ER over the Golgi apparatus to the plasma membrane. Our results indicate that COPII vesicles constitute a central hub for these processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.