Evidence mapPaperPMID 20524088Full record

ReviewCurrent hypertension reports2010

Inflammation and therapy for hypertension.

Cheryl L Laffer, Fernando Elijovich

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cheryl L LafferScott & White Memorial Hospital and Clinics, 2401 South 31st Street, Temple, TX 76508, USA.
Fernando Elijovich

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is currently accepted that hypertension, atherosclerosis, and diabetes are disorders with subtle or overt activation of inflammatory mediators. Therefore, it has become increasingly important to ascertain whether current antihypertensive drug families have proinflammatory or anti-inflammatory actions that modify the outcomes of their hemodynamic effects on blood pressure. We review the current state of knowledge about the effects of the major classes of available antihypertensive agents on inflammation and speculate on the possible contribution of these effects to observations in clinical trials. We suggest that a strategy of drug development specifically addressing inflammation in hypertension may provide increased benefit in terms of target organ damage, and we describe some examples of these promising developments.

Indexed as

Adrenergic beta-AntagonistsAntihypertensive AgentsCalcium Channel BlockersCytokinesDisease ProgressionEndothelin Receptor AntagonistsHumansHypertensionInflammationOxidative StressReceptors, EndothelinReceptors, MineralocorticoidRenin-Angiotensin SystemThiazidesAdrenergic beta-AntagonistsAntihypertensive AgentsCalcium Channel BlockersCytokinesEndothelin Receptor AntagonistsReceptors, EndothelinReceptors, MineralocorticoidThiazides

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.