Evidence map›Paper›PMID 20550665›Full record

ArticleBMC medical genetics2010

Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.

Ying Lin, Pengqiu Li, Li Cai, Ben Zhang, Xin Tang, Xuejun Zhang, Ying Li, Yang Xian, Yang Yang, Li Wang and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 16 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 16 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  9. Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Ying LinCenter for Human Molecular Biology & Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Pengqiu Li
Li Cai
Ben Zhang
Xin Tang
Xuejun Zhang
Ying Li
Yang Xian
Yang Yang
Li Wang
Fang Lu
Xiaoqi Liu
Shaoqin Rao
Ming Chen
Shi Ma
Yi Shi
Mingjing Bao
Jichuan Wu
Yan Yang
Jiyun Yang
Zhenglin Yang
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAt least twenty genes/loci were shown to be associated with type 2diabetes in European original populations. Five of these genes were shown to be associated with type 2 diabetes (T2D) in Chinese populations. The purpose of this study was to replicate the association of genetic vairants in the eight diabetes-related genes/loci with type 2 diabetes in a Han Chinese cohort from western part of China. Nineteen single nucleotide polymorphisms (SNPs) from the eight genes/loci including TCF7L2, HHEX, CDKAL1, SLC30A8, PPARG, IGF2BP2, KCNJ11, and CDKN2A/CDKN2B were genotyped in 1,529 cases and 1,439 controls in a Han Chinese population using the ABI SNaPshot method. The meta-analysis of the association between rs7903146 in TCF7L2 gene and T2D in the Han Chinese was performed.

resultsAmong the eight genes/loci examined, we found that four were significantly associated with T2D. Although previous studies showed that the association between the SNP rs7903146 in the TCF7L2 gene and T2D was controversial within the Han Chinese population, we have confirmed the significant association between the SNP rs7903146 in the TCF7L2 gene and T2D in both this study and the meta-analysis in the population. In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied.

conclusionsWe demonstrated that the variants in TCF7L2, CDKAL1, HHEX, and SLC30A8 genes are associated with T2D in a Han Chinese population.

Indexed as

Polymorphism, Single NucleotideTCF Transcription FactorsAnimalsAsian PeopleBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsChinaCricetinaeCricetulusCyclin-Dependent Kinase Inhibitor p16Diabetes MellitusDiabetes Mellitus, Type 2Genes, p16GenotypeHumansPopulation GroupsTranscription Factor 4Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsCyclin-Dependent Kinase Inhibitor p16TCF4 protein, humanTCF Transcription FactorsTranscription Factor 4Transcription Factors

Identifiers

PMID20550665
PMCPMC2894791
OpenAlexW2146409740

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.