ArticleCirculation. Cardiovascular genetics2010
A comprehensive genetic study on left atrium size in Caribbean Hispanics identifies potential candidate genes in 17p10.
Article in Circulation. Cardiovascular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Left Atrial Volume Index Predicts Atrial Fibrillation Recurrence after Catheter Ablation Only in Obese Patients-Brief Report.Diagnostics (Basel, Switzerland) · 2024Article
- Association between PNPLA3 rs738409 G variant and MRI cerebrovascular disease biomarkers.Journal of the neurological sciences · 2020Article
- MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function.Cell communication and signaling : CCS · 2020Article
- Clinical correlates and heritability of cardiac mechanics: The HyperGEN study.International journal of cardiology · 2019Article
- Article
- Giant left atrium with left lung damage: a case report.The Journal of international medical research · 2018Article
- Review
- Associates and Prognosis of Giant Left Atrium; Single Center Experience.Journal of cardiovascular ultrasound · 2017Article
- Factors Associated With Left Atrial Remodeling in the General Population.Circulation. Cardiovascular imaging · 2017Article
- A MicroRNA-Transcription Factor Blueprint for Early Atrial Arrhythmogenic Remodeling.BioMed research international · 2015Article
- Left atrial size is independently associated with cognitive function.The International journal of neuroscience · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLeft atrial (LA) enlargement is associated with cardiovascular disease and stroke. Genetic factors contributing to the LA dimension are poorly understood. We sought to map susceptibility genes for LA size in a large Dominican family data set and an independent population-based sample from the Northern Manhattan Study. METHODS AND
resultsOne hundred Dominican families comprising 1350 individuals were studied to estimate heritability and map quantitative trait loci for LA size using variance components analysis. LA dimension was measured by transthoracic echocardiography. A polygenic covariate screening was used to identify significant covariates. LA size had a moderate estimate of heritability (h(2)=0.42) after adjusting for significant covariates. Linkage analysis revealed suggestive evidence on chromosome 10p19 (D10S1423, MLOD=2.00) and 17p10 (D17S974, MLOD=2.05). Ordered subset analysis found significantly enhanced (P<0.05 for increase of LOD score) evidence for linkage at 17p10 (MLOD=2.9) in families with lower LDL level. Single nucleotide polymophisms (n=2233)were used to perform a peak-wide association mapping across 17p10 in 825 NOMAS individuals. Evidence for association were found in NTN1, MYH10, COX10, and MYOCD genes (P=0.00005 to 0.005).
conclusionsUsing nonbiased genome-wide linkage followed by peak-wide association analysis, we identified several possible susceptibility genes affecting LA size. Among them, MYOCD has been shown to serve as a key transducer of hypertrophic signals in cardiomyocytes. Our data support that polymorphisms in MYOCD modify LA size.
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