Evidence map›Paper›PMID 20563708›Full record

ReviewCurrent topics in microbiology and immunology2010

PI3Ks in lymphocyte signaling and development.

Klaus Okkenhaug, David A Fruman

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in microbiology and immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
11.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 62 citations in OpenAlex.

  1. Comparative Immunomodulatory Profiles ofJournal of microbiology and biotechnology · 2026
    Article
  2. Article
  3. Article
  4. Food for thought: Nutrient metabolism controlling early T cell development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  5. Roles of macrophages in lupus nephritis.Frontiers in pharmacology · 2024
    Review
  6. Article
  7. Review
  8. Review
  9. Study of Signal Transduction Pathways by Phospho-Protein Evaluation.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  10. Article
  11. Regulation of Hematopoietic Stem Cell Fate and Malignancy.International journal of molecular sciences · 2020
    Review
  12. ConcomitantThe Journal of experimental medicine · 2019
    Article
  13. Plasma proteome in multiple sclerosis disease progression.Annals of clinical and translational neurology · 2019
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL).Current topics in microbiology and immunology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Klaus OkkenhaugLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. klaus.okkenhaug@bbsrc.ac.uk
David A Fruman
Babraham Institute · GBUniversity of California, Irvine · US

Funding

Biotechnology and Biological Sciences Research Council BBS/E/B/0000C236Biotechnology and Biological Sciences Research Council JF19128
6 · The paper itself

Abstract

Lymphocyte development and function are regulated by tyrosine kinase and G-protein coupled receptors. Each of these classes of receptors activates phosphoinositide 3-kinase (PI3K). In this chapter, we summarize current understanding of how PI3K contributes to key aspects of the adaptive immune system.

Indexed as

AnimalsAntigen PresentationCell MovementChemotaxis, LeukocyteHumansImmunoglobulin Class SwitchingLymphocytesPhosphatidylinositol 3-KinasesReceptors, Antigen, B-CellReceptors, Antigen, T-CellSignal TransductionPhosphatidylinositol 3-KinasesReceptors, Antigen, B-CellReceptors, Antigen, T-Cell

Identifiers

PMID20563708
PMCPMC4499567
OpenAlexW25302644

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.