Evidence map›Paper›PMID 20607462›Full record

ReviewCurrent heart failure reports2010

Rubbing salt into wounds: hypertonic saline to assist with volume removal in heart failure.

Mark Liszkowski, Anju Nohria

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current heart failure reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06442280 (Enhanced Diuresis and Natriuresis in Acute Decompensated Heart Failure Patients Treated With SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06442280 phase4unknown statusstarted 2024, after this paper: background citation

Enhanced Diuresis and Natriuresis in Acute Decompensated Heart Failure Patients Treated With SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution: A Clinical Trial

Ran2024Enrolled544Registered outcomes4Posted comparisons0ConditionsDiabetes Type 2, Heart Failure Acute, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection FractionArmsDapagliflozin Tablet, Furosemide Injection, Hypertonic Saline Solution, 1 Ml
PMID 36607775PMID 21440872PMID 21885793PMID 22980301PMID 26240596PMID 35241246PMID 15963399PMID 32139695PMID 32709292PMID 32970396PMID 34447992other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Observational
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Salt and water imbalance in chronic heart failure.Internal and emergency medicine · 2011
    Article
  12. Retroelements and formation of chimeric retrogenes.Cellular and molecular life sciences : CMLS · 2004
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mark LiszkowskiBrigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Anju Nohria
Brigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditionally accepted management strategies for patients with heart failure include sodium and fluid restriction, neurohormonal blockade, and the use of loop diuretics to achieve and maintain euvolemia. Despite continued advances in medical and device therapy, fluid management remains a significant problem in patients with the cardiorenal syndrome (manifested as diuretic resistance and worsening renal function with more aggressive attempts at volume removal). This article examines the counterintuitive use of hypertonic saline as a potential therapy to facilitate diuresis in patients with decompensated heart failure and diuretic resistance. Low-volume hypertonic saline administration offsets counterproductive neurohormonal upregulation, transiently improves hemodynamics, and promotes renal sodium excretion with accompanied net water loss and preservation of renal function. This "new" therapeutic tool should be explored further as an adjunct to current medical therapies in the management of patients with refractory volume overload.

Indexed as

Cardiac Surgical ProceduresDrug ResistanceHeart FailureHemodynamicsHumansKidney Function TestsRenal InsufficiencyResuscitationSaline Solution, HypertonicShockSodium Potassium Chloride Symporter InhibitorsSaline Solution, HypertonicSodium Potassium Chloride Symporter Inhibitors

Identifiers

PMID20607462
OpenAlexW2033412784

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.