ArticleDiabetes2010
Fetal exposure to maternal type 1 diabetes is associated with renal dysfunction at adult age.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- The Contribution of Ultrasound and Doppler Studies on Impaired Intrauterine Conditions and the Development of Future Disease.Medicina (Kaunas, Lithuania) · 2026Review
- Protecting Kidney Health in the First 1000 Days: The Pediatrician's Role in Safeguarding the Weakest.Diseases (Basel, Switzerland) · 2026Review
- Prediction of Possible Adverse Effects of Gestational Diabetes Mellitus on Maternal and Fetal Glomeruli by Urine and Amniotic Fluid Podocyte Degradation Products.Diagnostics (Basel, Switzerland) · 2024Article
- Sex differences in fetal kidney reprogramming: the case in the renin-angiotensin system.Pediatric nephrology (Berlin, Germany) · 2024Review
- Programmable dual responsive system reconstructing nerve interaction with small-diameter tissue-engineered vascular grafts and inhibiting intimal hyperplasia in diabetes.Bioactive materials · 2022Article
- Nephron-deficient HSRA rats exhibit renal injury with age but have limited renal damage from streptozotocin-induced hyperglycemia.American journal of physiology. Renal physiology · 2021Article
- Programmed Adult Kidney Disease: Importance of Fetal Environment.Frontiers in physiology · 2020Review
- Normal foetal kidney volume in offspring of women treated for gestational diabetes.Endocrinology, diabetes & metabolism · 2019Article
- Renal Consequences of Gestational Diabetes Mellitus in Term Neonates: A Multidisciplinary Approach to the DOHaD Perspective in the Prevention and Early Recognition of Neonates of GDM Mothers at Risk of Hypertension and Chronic Renal Diseases in Later Life.Journal of clinical medicine · 2019Article
- Sex Difference In the Effect of Fetal Exposure to Maternal Diabetes on Insulin Secretion.Journal of the Endocrine Society · 2018Article
- Maternal obesity increases the risk of metabolic disease and impacts renal health in offspring.Bioscience reports · 2018Review
- Article
- Renal development in the fetus and premature infant.Seminars in fetal & neonatal medicine · 2017Review
- Article
- Epigenetics and Cardiovascular Disease in Diabetes.Current diabetes reports · 2015Review
- Birth weight, malnutrition and kidney-associated outcomes--a global concern.Nature reviews. Nephrology · 2015Review
- Article
- Nephron number and its determinants in early life: a primer.Pediatric nephrology (Berlin, Germany) · 2014Review
- Altered ureteric branching morphogenesis and nephron endowment in offspring of diabetic and insulin-treated pregnancy.PloS one · 2013Article
- Fetal programming of renal function.Pediatric nephrology (Berlin, Germany) · 2012Review
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn animal studies, hyperglycemia during fetal development reduces nephron numbers. We tested whether this observation translates into renal dysfunction in humans by studying renal functional reserve in adult offspring exposed in utero to maternal type 1 diabetes. RESEARCH DESIGN AND
methodsWe compared 19 nondiabetic offspring of type 1 diabetic mothers with 18 offspring of type 1 diabetic fathers (control subjects). Glomerular filtration rate ((51)Cr-EDTA clearance), effective renal plasma flow ((123)I-hippurate clearance), mean arterial pressure, and renal vascular resistances were measured at baseline and during amino acid infusion, which mobilizes renal functional reserve.
resultsOffspring of type 1 diabetic mothers were similar to control subjects for age (median 27, range 18-41, years), sex, BMI (23.1 ± 3.7 kg/m(2)), and birth weight (3,288 ± 550 vs. 3,440 ± 489 g). During amino acid infusion, glomerular filtration rate and effective renal plasma flow increased less in offspring of type 1 diabetic mothers than in control subjects: from 103 ± 14 to 111 ± 17 ml/min (8 ± 13%) vs. from 108 ± 17 to 128 ± 23 ml/min (19 ± 7%, P = 0.009) and from 509 ± 58 to 536 ± 80 ml/min (5 ± 9%) vs. from 536 ± 114 to 620 ± 140 ml/min (16 ± 11%, P = 0.0035). Mean arterial pressure and renal vascular resistances declined less than in control subjects: 2 ± 5 vs. -2 ± 3% (P = 0.019) and 3 ± 9 vs. -14 ± 8% (P = 0.001).
conclusionsReduced functional reserve may reflect a reduced number of nephrons undergoing individual hyperfiltration. If so, offspring of type 1 diabetic mothers may be predisposed to glomerular and vascular diseases.
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