Trial reportPreventive cardiology2010
A randomized clinical trial to assess the effect of statins on skeletal muscle function and performance: rationale and study design.
Trial report in Preventive cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- The influence of resting blood pressure on muscle strength in healthy adults.Blood pressure monitoring · 2018Trial
- The effect of high-dose atorvastatin on neural activity and cognitive function.American heart journal · 2018Trial
- The Effect of Atorvastatin on Habitual Physical Activity among Healthy Adults.Medicine and science in sports and exercise · 2016Trial
- Statin Use and Self-Reported Hindering Muscle Complaints in Older Persons: A Population Based Study.PloS one · 2016Trial
- A randomized trial of coenzyme Q10 in patients with confirmed statin myopathy.Atherosclerosis · 2015Trial
- Effect of statins on skeletal muscle function.Circulation · 2013 · on this mapTrial
- Atorvastatin increases exercise leg blood flow in healthy adults.Atherosclerosis · 2011Trial
- Sex-specific effect of aging on submaximal leg exercise hemodynamics in middle-aged and older adults.European journal of applied physiology · 2011Trial
- Relation of vitamin D level to maximal oxygen uptake in adults.The American journal of cardiology · 2011Trial
- Influence of Baseline Psychological Health on Muscle Pain During Atorvastatin Treatment.The Journal of cardiovascular nursingTrial
- A randomized trial of coenzyme Q10 in patients with statin myopathy: rationale and study design.Journal of clinical lipidologyTrial
- Article
- Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study.Journal of diabetes research · 2018Article
- Article
- Treatment of dyslipidemia with statins and physical exercises: recent findings of skeletal muscle responses.Arquivos brasileiros de cardiologia · 2015Review
- Relationships between physical activity and muscular strength among healthy adults across the lifespan.SpringerPlus · 2015Article
- The effects of statin medications on aerobic exercise capacity and training adaptations.Sports medicine (Auckland, N.Z.) · 2014Review
- Effects of Atorvastatin on Resting and Peak Exercise Blood Pressure among Normotensive Men and Women.Cholesterol · 2014Article
- Atorvastatin Treatment Does Not Alter Pulse Wave Velocity in Healthy Adults.International scholarly research notices · 2014Article
- 25(OH) vitamin D is associated with greater muscle strength in healthy men and women.Medicine and science in sports and exercise · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Hydroxymethylglutaryl-coenzyme A reductase inhibitors or statins are the most effective medications for reducing elevated concentrations of low-density lipoprotein cholesterol (LDL-C). Statins reduce cardiac events in patients with coronary artery disease and previously healthy persons. Current recommendations for LDL-C treatment goals indicate that more patients will be treated with higher doses of these medications. Statins have been extremely well-tolerated in controlled clinical trials but are increasingly recognized to produce skeletal muscle myalgia, cramps, and weakness. The reported frequency of such mild symptoms is not clear, and muscle performance has not been examined with these medications. Accordingly, the present investigation, the Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study, will recruit approximately 440 healthy persons. Participants will be randomly assigned to treatment with atorvastatin 80 mg/d or placebo. Handgrip, elbow and knee isometric and isokinetic strength, knee extensor endurance, and maximal aerobic exercise performance will be determined at baseline. Participants will undergo repeat testing after 6 months of treatment or after meeting the study definition of statin myalgia. This study will determine the effect of statins on skeletal muscle strength, endurance, and aerobic exercise performance and may ultimately help clinicians better evaluate statin-related muscle and exercise complaints.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.