Evidence map›Paper›PMID 20629636›Full record

ArticleClinical science (London, England : 1979)2010

Protein catabolism and impairment of skeletal muscle insulin signalling in heart failure.

P Christian Schulze

Abstract readComment
PubMed Publisher
In one paragraph

Article in Clinical science (London, England : 1979), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

P Christian SchulzeDivision of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA. pcs2121@columbia.edu
NewYork–Presbyterian Hospital · US

Funding

Cardiac and Skeletal Muscle Metabolism and Proteolysis in Heart FailureK23HL095742 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SCHULZE, P. CHRISTIAN · 2009 to 2013
$677k
NHLBI NIH HHS K23 HL095742
6 · The paper itself

Abstract

Derangements in systemic and local metabolism develop in patients with CHF [chronic HF (heart failure)] and contribute to the progression of the disease. Impaired skeletal muscle metabolism, morphology and function leading to exercise intolerance are hallmarks of the syndrome of CHF. These changes result in abnormal glucose and lipid metabolism, and the associated insulin resistance, which contribute to progression of skeletal muscle catabolism and development of muscle atrophy in patients with advanced HF. In the present issue of Clinical Science, Toth and co-workers demonstrate the impairment of skeletal muscle protein metabolism in patients with HF, and specifically show an impaired anabolic response in the skeletal muscle of these patients following a period of nutritional deficiency.

Indexed as

Heart FailureHumansInsulin ResistanceMuscle ProteinsMuscle, SkeletalSignal TransductionMuscle Proteins

Identifiers

PMID20629636
OpenAlexW2141360551

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.